Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,937 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

7-night Eastern Caribbean With Puerto Rico Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
5/31/25
14-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
5/31/25
 
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7-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
5/31/25
 
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7-night Galapagos Outer Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
6/1/25
From
$8,588
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
6/2/25
 
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9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/2/25
From
$4,349
4-night Catalina & Ensenada Cruise

Roundtrip Los Angeles

Cruise Line
Royal Caribbean International
Cruise Ship
Navigator of the Seas
Departs
6/2/25
4-night Amazon Explorer Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
6/3/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/4/25
From
$3,449
113-night World Cruise - Roundtrip Sydney

Roundtrip Sydney

Cruise Line
Princess Cruises
Cruise Ship
Crown Princess
Departs
6/4/25
 
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10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/4/25
 
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7-night Ecuador and Its Galápagos Islands Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
6/4/25
 
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11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
6/4/25
From
$8,796
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
6/5/25
From
$19,663
10-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
6/5/25
From
$11,647
11-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
6/5/25
From
$11,791
10-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
6/5/25
 
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11-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
6/5/25
 
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16-night Galápagos Southern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
6/5/25
 
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9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
6/5/25
 
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10-night Quito and Galápagos Inner Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
6/6/25
 
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113-night World Cruise - Roundtrip Brisbane

Roundtrip Brisbane

Cruise Line
Princess Cruises
Cruise Ship
Crown Princess
Departs
6/6/25
 
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10-night Wild Galapagos & Peru Escape Cruise

Lima to Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
6/6/25
From
$12,589
7-night West Galapagos Expedition Cruise

Puerto Ayora to Baltra Island

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
6/6/25
 
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