Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,914 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

7-night Galapagos Southern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
6/14/25
From
$6,791
7-night Galapagos Northern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
6/14/25
From
$5,811
7-night Eastern Caribbean With Puerto Rico Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
6/14/25
 
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14-night Caribbean East/West Adventurer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
6/14/25
From
$2,169
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
6/14/25
 
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14-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
6/14/25
 
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7-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
6/14/25
From
$13,300
7-night Eastern Caribbean Cruise

Roundtrip Port Canaveral

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian New Build
Departs
6/14/25
 
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7-night Galápagos – Wildlife Wonderland Cruise/Land Package

Quito to Guayaquil

Cruise Line
Tauck Cruises
Cruise Ship
Santa Cruz II
Departs
6/14/25
From
$8,490
3-night Amazon Discovery Cruise

Iquitos to Nauta

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
6/14/25
 
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7-night Amazon Expeditions Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
6/14/25
 
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7-night Galapagos Outer Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
6/15/25
From
$7,880
7-night Eastern Caribbean Cruise

Roundtrip Miami

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Escape
Departs
6/15/25
From
$1,129
37-night Pacific & Caribbean Stars - 2025 World Cruise Segment

Papeete to New York City

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
6/16/25
From
$9,499
17-night Islands of the Pacific - 2025 World Cruise Segment

Papeete to San Diego

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
6/16/25
From
$4,649
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
6/16/25
From
$5,774
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/16/25
 
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4-night Amazon Explorer Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
6/17/25
 
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7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/18/25
 
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10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
6/18/25
 
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7-night Ecuador and Its Galápagos Islands Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
6/18/25
From
$6,379
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
6/18/25
From
$8,796
11-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
6/19/25
From
$8,755
7-night Wild Galapagos Escape Cruise

Roundtrip Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
6/19/25
From
$11,665