Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,978 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

7-night Galapagos Northern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
5/24/25
From
$9,151
7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
5/24/25
From
$3,599
14-night Caribbean East/West Adventurer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
5/24/25
 
Call For Pricing
7-night Galapagos Southern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
5/24/25
From
$6,307
10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
5/24/25
 
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7-night Eastern Caribbean Cruise

Roundtrip Port Canaveral

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian New Build
Departs
5/24/25
 
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31-night Asia and Alaska Cruise

Yokohama to Seattle

Cruise Line
Cunard Line
Cruise Ship
Queen Elizabeth
Departs
5/24/25
 
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3-night Amazon Discovery Cruise

Iquitos to Nauta

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
5/24/25
 
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7-night Amazon Expeditions Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
5/24/25
 
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7-night Galapagos Inner Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
5/25/25
From
$9,088
10-night From the Inca Empire to the Peruvian Amazon Cruise/Land Package

Roundtrip Lima

Cruise Line
Avalon Waterways
Cruise Ship
Delfin III
Departs
5/25/25
 
Call For Pricing
7-night Eastern Caribbean Cruise

Roundtrip Miami

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Escape
Departs
5/25/25
6-night Wild Galapagos Escape Cruise

Roundtrip Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
5/27/25
From
$8,842
4-night Amazon Explorer Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
5/27/25
 
Call For Pricing
57-night Epic Tropical Vistas - 2025 World Cruise Segment

Auckland to New York City

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
5/28/25
From
$15,699
37-night Polynesian Parade - 2025 World Cruise Segment

Auckland to San Diego

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
5/28/25
From
$10,599
10-night Magic of Colombia with 3 nights Medellin Cruise/Land Package

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
5/28/25
From
$4,774
7-night Magic of Colombia with 3 nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package

Medellin to Panama City

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
5/28/25
 
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16-night Galápagos Southern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
5/29/25
From
$23,447
10-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
5/29/25
From
$15,431
11-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
5/29/25
From
$15,575
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
5/29/25
From
$17,759
10-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
5/29/25
From
$9,743
11-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
5/29/25
From
$9,887