Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
789 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/19/25
|
From
$14,699
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$11,999
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$16,399
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/22/25
|
From
$4,449
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/29/25
|
From
$4,299
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/20/25
|
From
$3,999
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/27/25
|
From
$3,999
|
10-night Canada & New England Cruise
Boston to Quebec City |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Shadow
|
Departs
7/14/24
|
Call For Pricing
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
9/16/24
|
Call For Pricing
|
9-night Canada & New England Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
9/19/24
|
From
$529
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
9/21/24
|
From
$324
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
9/22/24
|
From
$445
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Jewel of the Seas
|
Departs
9/22/24
|
From
$591
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
9/26/24
|
From
$278
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
9/28/24
|
From
$389
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
9/29/24
|
From
$566
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Jewel of the Seas
|
Departs
9/29/24
|
From
$689
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
9/30/24
|
From
$398
|
9-night Canada & New England Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/3/24
|
From
$529
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/5/24
|
From
$333
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Jewel of the Seas
|
Departs
10/6/24
|
From
$584
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/10/24
|
From
$305
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/12/24
|
From
$389
|
7-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Brilliance of the Seas
|
Departs
10/12/24
|
From
$511
|