Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
816 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
11-night Southeast Canadian Explorations Cruise
Boston to Montreal |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
10/1/24
|
From
$4,799
|
11-night Boston Sights, Warm Caribbean Nights Cruise
Boston to San Juan |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
10/23/24
|
From
$2,799
|
11-night Southeast Canadian Explorations Cruise
Boston to Montreal |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
9/26/25
|
From
$4,699
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
5/23/24
|
From
$6,999
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/6/24
|
From
$6,849
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/22/24
|
From
$24,999
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/22/24
|
From
$6,399
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$15,999
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$5,299
|
12-night Eastern Seaboard Explorer Cruise
Boston to Montreal |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mars
|
Departs
8/31/24
|
From
$5,999
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/28/24
|
From
$39,999
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/28/24
|
From
$13,299
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/2/24
|
Call For Pricing
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/7/24
|
From
$10,499
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/21/24
|
Call For Pricing
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/23/24
|
From
$4,199
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/30/24
|
From
$4,199
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/7/24
|
From
$4,499
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/14/24
|
From
$3,499
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/21/24
|
From
$3,499
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/28/24
|
From
$3,999
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
1/4/25
|
From
$3,999
|
11-night Heart of the Delta Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
1/9/25
|
Call For Pricing
|
11-night Heart of the Delta Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
1/23/25
|
Call For Pricing
|