Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
802 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Star
|
Departs
11/4/24
|
Call For Pricing
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
11/6/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
11/9/24
|
Call For Pricing
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
11/10/24
|
Call For Pricing
|
10-night American Revolution Cruise
Roundtrip Baltimore |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
11/10/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
11/12/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Symphony
|
Departs
11/15/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
11/15/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
11/19/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
11/21/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
11/22/24
|
Call For Pricing
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
11/23/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
11/25/24
|
Call For Pricing
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Fernandina Beach |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
11/27/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Symphony
|
Departs
11/29/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
12/1/24
|
Call For Pricing
|
7-night Historic Mississippi Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/6/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
12/7/24
|
Call For Pricing
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/7/24
|
Call For Pricing
|
7-night Historic Mississippi Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/12/24
|
Call For Pricing
|
8-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Symphony
|
Departs
12/13/24
|
Call For Pricing
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
12/15/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/19/24
|
Call For Pricing
|
7-night Historic South & Golden Isles Christmas Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/21/24
|
Call For Pricing
|