Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
800 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$5,299
|
11-night Southeast Canadian Explorations Cruise
Boston to Montreal |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
10/1/24
|
From
$4,999
|
11-night In the Path of Cartier Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Nautica
|
Departs
9/25/24
|
From
$4,799
|
11-night Southeast Canadian Explorations Cruise
Boston to Montreal |
Cruise Line
Windstar Cruises
|
Cruise Ship
Star Pride
|
Departs
9/26/25
|
From
$4,799
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/30/24
|
From
$4,699
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
8/30/25
|
From
$4,598
|
11-night Canadian Connoisseur Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/5/25
|
From
$4,499
|
11-night In the Path of Cartier Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Nautica
|
Departs
10/17/24
|
From
$4,449
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/22/25
|
From
$4,449
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
9/19/25
|
From
$4,448
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
10/9/25
|
From
$4,448
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
10/7/24
|
From
$4,398
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/7/24
|
From
$4,299
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/29/25
|
From
$4,299
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
11/23/24
|
From
$4,249
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
9/17/24
|
From
$4,098
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
8/28/24
|
From
$4,048
|
35-night Perfect Caribbean Escape & Southern Caribbean Cruise
Boston to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/19/24
|
From
$4,019
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/28/24
|
From
$3,999
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
1/4/25
|
From
$3,999
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/20/25
|
From
$3,999
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/27/25
|
From
$3,999
|
17-Day Voyage Of The Vikings
Boston to Rotterdam |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
7/19/25
|
From
$3,734
|
7-night New Orleans & Southern Charms Cruise
Roundtrip New Orleans |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/14/24
|
From
$3,499
|