Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
824 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/22/24
|
From
$24,999
|
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$16,399
|
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$15,999
|
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/14/25
|
From
$15,499
|
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/19/25
|
From
$14,699
|
|
10-night Canada & New England Cruise
Boston to Quebec City |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Shadow
|
Departs
7/14/24
|
From
$14,350
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$11,999
|
|
11-night Fall Foliage Journey Cruise – Boston to Montreal
Boston to Montreal |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Splendor
|
Departs
10/11/25
|
From
$11,999
|
|
11-night Fall Season Colors Cruise
Boston to Montreal |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Grandeur
|
Departs
10/1/24
|
From
$11,899
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/14/25
|
From
$10,999
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/19/25
|
From
$9,999
|
|
10-night A Musical Cruise in Nova Scotia and the East Coast of the United States Cruise
Roundtrip Boston |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Champlain
|
Departs
10/15/25
|
From
$9,370
|
|
5-night Wild Greenland Escape Cruise
Roundtrip Boston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
7/13/24
|
From
$9,352
|
|
5-night Wild Greenland Escape Cruise
Roundtrip Boston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
7/18/24
|
From
$9,352
|
|
41-night Caribbean & Amazon Icons Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$8,799
|
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/6/24
|
From
$7,699
|
|
18-night Bermuda and Quebec Explorer Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Nautica
|
Departs
9/18/24
|
From
$7,099
|
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
5/23/24
|
From
$6,999
|
|
25-Day Canada, New England & Iceland
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Volendam
|
Departs
7/12/25
|
From
$6,374
|
|
35-Day Voyage Of The Vikings
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
7/19/25
|
From
$6,362
|
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/22/24
|
From
$6,299
|
|
12-night Eastern Seaboard Explorer Cruise
Boston to Montreal |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mars
|
Departs
8/31/24
|
From
$5,999
|
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$5,299
|
|
11-night In the Path of Cartier Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Nautica
|
Departs
9/25/24
|
From
$4,799
|