Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
802 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
16-night Island Inspiration Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$3,049
|
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
8/28/24
|
From
$4,148
|
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
9/17/24
|
From
$4,148
|
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
10/7/24
|
From
$4,448
|
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
8/30/25
|
From
$4,598
|
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
9/19/25
|
From
$4,448
|
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
10/9/25
|
From
$4,448
|
|
15-night Grand New England Cruise/Land Package
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
6/30/24
|
Call For Pricing
|
|
15-night Grand New England Cruise/Land Package
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
7/14/24
|
Call For Pricing
|
|
15-night Grand New England Cruise/Land Package
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
8/11/24
|
Call For Pricing
|
|
14-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
2/1/26
|
From
$1,179
|
|
14-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
2/22/26
|
From
$1,229
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/14/25
|
From
$10,999
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/19/25
|
From
$9,999
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to Alton |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$11,999
|
|
14-night Southern Caribbean Cruise
Boston to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
11/9/24
|
From
$1,789
|
|
14-night Eastern Caribbean: San Juan & Antilles Cruise
Boston to Miami |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/18/25
|
From
$2,199
|
|
14-night Eastern & Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Viva
|
Departs
1/10/26
|
From
$1,548
|
|
14-night Eastern & Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Viva
|
Departs
1/24/26
|
From
$1,548
|
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
11/2/24
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Star
|
Departs
11/4/24
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
11/6/24
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
11/10/24
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore, MD to Jacksonville (Amelia Island), FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
11/1/25
|
Call For Pricing
|