Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
815 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
41-night Caribbean & Amazon Icons Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$8,799
|
35-night Perfect Caribbean Escape & Southern Caribbean Cruise
Boston to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/19/24
|
From
$4,019
|
35-Day Voyage Of The Vikings
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
7/19/25
|
From
$6,362
|
25-night Southern Caribbean / Eastern Caribbean Wayfarer Cruise
Boston to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
11/9/24
|
From
$3,119
|
25-Day Canada, New England & Iceland
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Volendam
|
Departs
7/12/25
|
From
$6,374
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
5/31/24
|
Call For Pricing
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
6/18/24
|
Call For Pricing
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Symphony
|
Departs
8/30/24
|
Call For Pricing
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
5/23/25
|
Call For Pricing
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
6/13/25
|
Call For Pricing
|
21-night Perfect Caribbean Escape Cruise
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/19/24
|
From
$2,559
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/14/25
|
From
$15,499
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/19/25
|
From
$14,699
|
21-night Mississippi River Odyssey Cruise
New Orleans to Red Wing |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/20/25
|
From
$16,399
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/22/24
|
From
$24,999
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
7/27/24
|
From
$15,999
|
21-night Grand Mississippi Voyage Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
9/28/24
|
From
$39,999
|
21-night Eastern Caribbean: San Juan & Antilles Cruise
Boston to Miami |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/18/25
|
From
$3,204
|
18-night Bermuda and Quebec Explorer Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Nautica
|
Departs
9/18/24
|
From
$6,099
|
17-night Greenland & Canada Cruise
Roundtrip Boston |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
8/11/24
|
Call For Pricing
|
17-Day Voyage Of The Vikings
Boston to Rotterdam |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
7/19/25
|
From
$3,734
|
16-night Transatlantic Cruise
Galveston to Barcelona |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
3/16/26
|
From
$1,068
|
16-night Island Inspiration Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$3,049
|
15-night Maple Explorer Cruisetour #2E
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
8/28/24
|
From
$4,048
|