Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
816 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/29/26
|
Call For Pricing
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/15/26
|
Call For Pricing
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/1/26
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore, MD to Jacksonville (Amelia Island), FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
10/27/26
|
Call For Pricing
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
7/12/26
|
Call For Pricing
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
5/16/26
|
Call For Pricing
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
5/2/26
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Allure of the Seas
|
Departs
4/19/26
|
From
$689
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
4/18/26
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Allure of the Seas
|
Departs
4/12/26
|
From
$689
|
|
8-night Southeast Coast & Bahamas Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
4/10/26
|
From
$529
|
|
7-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
4/5/26
|
From
$828
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Allure of the Seas
|
Departs
4/5/26
|
From
$839
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
4/4/26
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Viva
|
Departs
4/4/26
|
From
$949
|
|
8-night Southeast Coast & Bahamas Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
4/2/26
|
From
$557
|
|
7-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
3/29/26
|
From
$798
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Allure of the Seas
|
Departs
3/29/26
|
From
$799
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Viva
|
Departs
3/28/26
|
From
$978
|
|
7-night Western Caribbean Cruise
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
3/22/26
|
From
$798
|
|
12-night Caribbean Islander Cruise
Galveston to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Regal Princess
|
Departs
3/22/26
|
From
$1,119
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Allure of the Seas
|
Departs
3/22/26
|
From
$759
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
3/21/26
|
Call For Pricing
|
|
12-night Southern Caribbean Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
3/21/26
|
From
$975
|