Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
1,158 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/4/25
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
5/4/25
|
From
$4,000
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
5/6/25
|
Call For Pricing
|
|
9-night Bermuda & Perfect Day Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
5/8/25
|
Call For Pricing
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
5/8/25
|
From
$935
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
5/9/25
|
Call For Pricing
|
|
7-night Bermuda Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Jewel
|
Departs
5/9/25
|
From
$756
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/10/25
|
Call For Pricing
|
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore, MD |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
5/10/25
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
5/11/25
|
From
$3,013
|
|
8-night Southeast Sea Islands Cruise
Charleston, SC to Amelia Island, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
5/11/25
|
Call For Pricing
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
5/12/25
|
From
$1,340
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
5/12/25
|
Call For Pricing
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/16/25
|
Call For Pricing
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
5/16/25
|
Call For Pricing
|
|
7-night Bermuda Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Jewel
|
Departs
5/16/25
|
From
$776
|
|
8-night Southeast Sea Islands Cruise
Charleston, SC to Amelia Island, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
5/16/25
|
Call For Pricing
|
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
5/17/25
|
Call For Pricing
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
5/17/25
|
From
$1,340
|
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
5/17/25
|
Call For Pricing
|
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore, MD |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
5/17/25
|
Call For Pricing
|
|
6-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
5/18/25
|
From
$1,853
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
5/19/25
|
Call For Pricing
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
5/20/25
|
Call For Pricing
|