Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
1,156 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
11-night Canada, Maine & Boston Cruise
Roundtrip Boston |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Silhouette
|
Departs
9/29/25
|
From
$2,128
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
9/29/25
|
From
$465
|
|
7-night Canada & New England Cruise
Boston to Quebec City |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
10/3/25
|
From
$1,229
|
|
7-night Canada & New England: Unesco Sites & Quebecois Nights Cruise
Boston to Quebec |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/4/25
|
From
$1,263
|
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/4/25
|
From
$668
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/4/25
|
From
$556
|
|
11-night Canadian Connoisseur Voyage
Boston to Montreal |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/5/25
|
From
$4,999
|
|
6-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
10/5/25
|
From
$833
|
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Brilliance of the Seas
|
Departs
10/5/25
|
From
$795
|
|
10-night Classic Canada & New England Cruise
Boston to Quebec City |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
10/9/25
|
From
$1,868
|
|
15-night Maple Explorer Cruisetour #2C
Boston to Toronto |
Cruise Line
Princess Cruises
|
Cruise Ship
Majestic Princess
|
Departs
10/9/25
|
From
$4,819
|
|
9-night Canada & New England Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/9/25
|
From
$853
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/9/25
|
From
$521
|
|
10-night Boston To Fort Lauderdale Cruise
Boston to Ft. Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Silhouette
|
Departs
10/10/25
|
From
$1,282
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
10/10/25
|
Call For Pricing
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
10/10/25
|
Call For Pricing
|
|
11-night Fall Foliage Journey Cruise
Boston to Montreal |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Splendor
|
Departs
10/11/25
|
From
$9,300
|
|
8-night Western Caribbean & Perfect Day
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
10/11/25
|
From
$908
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Patriot
|
Departs
10/11/25
|
Call For Pricing
|
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Brilliance of the Seas
|
Departs
10/12/25
|
From
$776
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/13/25
|
From
$522
|
|
10-night A Musical Cruise in Nova Scotia and the East Coast of the United States Cruise
Roundtrip Boston |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Champlain
|
Departs
10/15/25
|
From
$10,590
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
10/16/25
|
Call For Pricing
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
10/16/25
|
Call For Pricing
|