Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
1,155 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Halifax & Bermuda Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Breakaway
|
Departs
5/31/26
|
From
$1,028
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Symphony of the Seas
|
Departs
5/31/26
|
From
$1,031
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
6/1/26
|
Call For Pricing
|
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore, MD |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Legend
|
Departs
6/1/26
|
Call For Pricing
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
6/2/26
|
Call For Pricing
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
6/2/26
|
Call For Pricing
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
6/4/26
|
From
$684
|
|
7-night Canada & New England Cruise: Unesco Sites & Quebecois Nights
Boston to Quebec City |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
6/6/26
|
From
$1,604
|
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
6/6/26
|
From
$902
|
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore, MD |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
6/6/26
|
Call For Pricing
|
|
14-night Canada & New England: Unesco Sites & Nights Collector Cruise
Roundtrip Boston |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
6/6/26
|
From
$3,094
|
|
7-night Halifax & Bermuda Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Breakaway
|
Departs
6/7/26
|
From
$1,028
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Symphony of the Seas
|
Departs
6/7/26
|
From
$1,267
|
|
10-night New England Explorer Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Patriot
|
Departs
6/7/26
|
Call For Pricing
|
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
6/8/26
|
Call For Pricing
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
6/8/26
|
From
$780
|
|
9-night Bermuda & Perfect Day Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
6/11/26
|
From
$1,052
|
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
6/12/26
|
Call For Pricing
|
|
7-night Potomac River & Chesapeake Bay Cruise
Baltimore, MD to Washington, DC |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Independence
|
Departs
6/13/26
|
Call For Pricing
|
|
14-night The Big Easy To The Gateway City Cruise
New Orleans to St. Louis (Alton) |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/13/26
|
From
$9,999
|
|
21-night Mississippi River Odyssey Cruise
New Orleans to St. Paul |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
6/13/26
|
From
$15,998
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
6/13/26
|
From
$781
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Symphony of the Seas
|
Departs
6/14/26
|
From
$1,010
|
|
14-night Grand New England Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Pioneer
|
Departs
6/14/26
|
Call For Pricing
|