Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
1,156 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
4-night Very Merrytime Western Caribbean Cruise From Galveston
Roundtrip Galveston |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Magic
|
Departs
12/3/25
|
From
$964
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
12/4/25
|
From
$396
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/4/25
|
Call For Pricing
|
|
8-night Southeast Sea Islands Cruise
Charleston, SC to Amelia Island, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/5/25
|
Call For Pricing
|
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Liberty
|
Departs
12/6/25
|
Call For Pricing
|
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
12/6/25
|
From
$4,499
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
12/7/25
|
From
$784
|
|
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
12/7/25
|
From
$726
|
|
4-night Very Merrytime Western Caribbean Cruise From Galveston
Roundtrip Galveston |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Magic
|
Departs
12/7/25
|
From
$924
|
|
6-night Western Caribbean With Mexico Cruise
Roundtrip Galveston |
Cruise Line
Princess Cruises
|
Cruise Ship
Regal Princess
|
Departs
12/8/25
|
From
$848
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
12/8/25
|
From
$447
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/10/25
|
Call For Pricing
|
|
8-night Southeast Coast & Bahamas Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
12/11/25
|
From
$721
|
|
4-night Very Merrytime Western Caribbean Cruise From Galveston
Roundtrip Galveston |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Magic
|
Departs
12/11/25
|
From
$948
|
|
8-night Southeast Sea Islands Cruise
Charleston, SC to Amelia Island, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
12/11/25
|
Call For Pricing
|
|
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan
Roundtrip Galveston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Viva
|
Departs
12/13/25
|
From
$1,146
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
12/13/25
|
From
$465
|
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Symphony
|
Departs
12/13/25
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
12/14/25
|
From
$703
|
|
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
12/14/25
|
From
$696
|
|
7-night Western Caribbean With Mexico Cruise
Roundtrip Galveston |
Cruise Line
Princess Cruises
|
Cruise Ship
Regal Princess
|
Departs
12/14/25
|
From
$589
|
|
4-night Very Merrytime Western Caribbean Cruise From Galveston
Roundtrip Galveston |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Magic
|
Departs
12/15/25
|
From
$1,240
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
12/16/25
|
Call For Pricing
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
12/18/25
|
From
$410
|