Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
1,156 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Canada & New England Cruise: Portland & Bar Harbor
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
10/17/25
|
From
$1,182
|
|
5-night Bermuda Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/18/25
|
From
$667
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/18/25
|
From
$458
|
|
14-night Eastern Caribbean: San Juan & Antilles Cruise
Boston to Miami |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/18/25
|
From
$2,059
|
|
21-night Eastern Caribbean: San Juan & Antilles Cruise
Boston to Miami |
Cruise Line
Holland America Line
|
Cruise Ship
Zuiderdam
|
Departs
10/18/25
|
From
$2,905
|
|
7-night Yankee Seaports Cruise
Boston to New York City |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Patriot
|
Departs
10/18/25
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
10/19/25
|
From
$883
|
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Brilliance of the Seas
|
Departs
10/19/25
|
From
$833
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
10/22/25
|
Call For Pricing
|
|
9-night Canada & New England Cruise
Roundtrip Baltimore |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Vision of the Seas
|
Departs
10/23/25
|
From
$853
|
|
4-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/23/25
|
From
$411
|
|
7-night Bermuda Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
10/24/25
|
Call For Pricing
|
|
7-night Mississippi Delta Explorer Cruise
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
10/25/25
|
From
$7,699
|
|
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
10/25/25
|
From
$957
|
|
7-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Harmony of the Seas
|
Departs
10/26/25
|
From
$847
|
|
7-night Canada Cruise
Roundtrip Boston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Brilliance of the Seas
|
Departs
10/26/25
|
From
$742
|
|
16-night Island Inspiration Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$3,699
|
|
41-night Caribbean & Amazon Icons Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$9,199
|
|
5-night Western Caribbean Cruise
Roundtrip Galveston |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Mariner of the Seas
|
Departs
10/27/25
|
From
$437
|
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
10/28/25
|
Call For Pricing
|
|
4-night Caribbean Getaway With Cozumel Cruise
Roundtrip Galveston |
Cruise Line
Princess Cruises
|
Cruise Ship
Regal Princess
|
Departs
10/29/25
|
From
$884
|
|
11-night Mississippi Explorer Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
10/30/25
|
Call For Pricing
|
|
8-night Lower Mississippi River
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
10/31/25
|
Call For Pricing
|
|
14-night East Coast Inland Passage Cruise
Baltimore, MD to Amelia Island, FL |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
10/31/25
|
Call For Pricing
|