Spectacular mountains. Shimmering lakes. Stunning vistas. The Pacific Northwest is the gateway to Canada and Alaska and offers more outdoor activities than there are days to enjoy them. From clamming to crabbing, white-water rafting to windsurfing, and canoeing to camping, there’s so much to do before or after any cruise. It’s the perfect blend of nature, culture, history and adventure as this region includes vibrant city life, lush landscapes, the San Juan Islands, the Columbia River Gorge, Crater Lake National Park, Mount Hood, world-class golf along the rugged coast, and multiple National Parks and monuments.
1,110 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
8-night Columbia and Snake Rivers Cruise
Portland to Clarkston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
10/31/25
|
Call For Pricing
|
|
6-night Columbia River Gorge Cruise
Roundtrip Portland |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Harmony
|
Departs
11/7/25
|
Call For Pricing
|
|
8-night Columbia and Snake Rivers Cruise
Portland, OR to Clarkston, WA |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Harmony
|
Departs
3/27/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constitution
|
Departs
3/28/26
|
Call For Pricing
|
|
7-night Columbia And Snake Rivers: Food, Wine, And History Cruise
Portland to Clarkston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Sea Bird
|
Departs
3/28/26
|
From
$6,126
|
|
6-night Columbia River Gorge Cruise
Roundtrip Portland |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
3/28/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constellation
|
Departs
3/30/26
|
Call For Pricing
|
|
8-night Columbia and Snake Rivers Cruise
Portland to Clarkston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Song
|
Departs
3/31/26
|
Call For Pricing
|
|
6-night Columbia River Gorge Cruise
Roundtrip Portland |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
4/2/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constitution
|
Departs
4/4/26
|
Call For Pricing
|
|
7-night Columbia And Snake Rivers: Food, Wine, And History Cruise
Portland to Clarkston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Sea Bird
|
Departs
4/4/26
|
From
$6,126
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constellation
|
Departs
4/6/26
|
Call For Pricing
|
|
6-night Columbia River Gorge Cruise
Roundtrip Portland |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
4/7/26
|
Call For Pricing
|
|
8-night Columbia and Snake Rivers Cruise
Portland, OR to Clarkston, WA |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Harmony
|
Departs
4/10/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constitution
|
Departs
4/11/26
|
Call For Pricing
|
|
7-night Columbia And Snake Rivers: Food, Wine, And History Cruise
Portland to Clarkston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Sea Bird
|
Departs
4/11/26
|
From
$6,840
|
|
8-night Columbia and Snake Rivers Cruise
Portland to Clarkston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Pride
|
Departs
4/12/26
|
Call For Pricing
|
|
6-night Columbia River Gorge Cruise
Roundtrip Portland |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
4/12/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constellation
|
Departs
4/13/26
|
Call For Pricing
|
|
8-night Columbia and Snake Rivers Cruise
Portland to Clarkston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Song
|
Departs
4/14/26
|
Call For Pricing
|
|
8-night Columbia and Snake Rivers Cruise
Portland to Clarkston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Jazz
|
Departs
4/17/26
|
Call For Pricing
|
|
7-night Puget Sound and San Juan Islands Cruise
Roundtrip Seattle |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Constitution
|
Departs
4/18/26
|
Call For Pricing
|
|
7-night Columbia And Snake Rivers: Food, Wine, And History Cruise
Portland to Clarkston |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Sea Bird
|
Departs
4/18/26
|
From
$6,840
|
|
7-night Great Bear Rainforest Cruise
Roundtrip Seattle |
Cruise Line
Holland America Line
|
Cruise Ship
Noordam
|
Departs
4/19/26
|
From
$1,156
|