Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,941 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

Itinerary	Cruise Line	Cruise Ship	Departing	From Price
10-night Quito and Galápagos Inner Loop Cruise/Land Package Roundtrip Quito	Cruise Line Celebrity Cruises	Cruise Ship Celebrity Flora	Departs 5/9/25	$11,525 From $11,525 See Itinerary
11-night Quito and Galápagos Inner Loop Cruise/Land Package Roundtrip Quito	Cruise Line Celebrity Cruises	Cruise Ship Celebrity Flora	Departs 5/9/25	$11,645 From $11,645 See Itinerary
33-night Panama Canal, Caribbean and Bermuda Cruise Los Angeles to New York City	Cruise Line Silversea Cruises	Cruise Ship Silver Shadow	Departs 5/9/25	Call For Pricing Call For Pricing See Itinerary
12-night From the Inca Empire to the Peruvian Amazon with the Nazca Lines Cruise/Land Package Roundtrip Lima	Cruise Line Avalon Waterways	Cruise Ship Delfin III	Departs 5/9/25	$7,477 From $7,477 See Itinerary
14-night Peru and the Galápagos Islands Cruise/Land Package Lima to Guayaquil	Cruise Line Tauck Cruises	Cruise Ship Isabela II	Departs 5/9/25	$14,490 From $14,490 See Itinerary
14-night West & East Galapagos Expedition Cruise Roundtrip Puerto Ayora	Cruise Line Aqua Expeditions	Cruise Ship Aqua Mare	Departs 5/9/25	Call For Pricing Call For Pricing See Itinerary
7-night Cabo, Vallarta & Mazatlan Cruise Roundtrip Los Angeles	Cruise Line Royal Caribbean International	Cruise Ship Navigator of the Seas	Departs 5/9/25	$626 From $626 See Itinerary
11-night Pacific Coast Cruise Los Angeles to Fuerte Amador(Panama City)	Cruise Line Silversea Cruises	Cruise Ship Silver Shadow	Departs 5/9/25	$4,500 From $4,500 See Itinerary
7-night Galapagos Northern Loop Cruise Roundtrip Isla Baltra	Cruise Line Celebrity Cruises	Cruise Ship Celebrity Xpedition	Departs 5/10/25	$7,731 From $7,731 See Itinerary
7-night Wonders of Colombia Cruise Cartagena to Barranquilla	Cruise Line AmaWaterways	Cruise Ship AmaMagdalena	Departs 5/10/25	$3,599 From $3,599 See Itinerary
14-night Caribbean East/West Adventurer Cruise Roundtrip Ft. Lauderdale	Cruise Line Princess Cruises	Cruise Ship Enchanted Princess	Departs 5/10/25	Call For Pricing Call For Pricing See Itinerary
7-night Galapagos Southern Loop Cruise Roundtrip Isla Baltra	Cruise Line Celebrity Cruises	Cruise Ship Celebrity Xploration	Departs 5/10/25	$6,211 From $6,211 See Itinerary
10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package Cartagena to Barranquilla	Cruise Line AmaWaterways	Cruise Ship AmaMagdalena	Departs 5/10/25	Call For Pricing Call For Pricing See Itinerary
7-night Galápagos Islands Cruise Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)	Cruise Line Silversea Cruises	Cruise Ship Silver Origin	Departs 5/10/25	$14,000 From $14,000 See Itinerary
7-night Eastern Caribbean Cruise Roundtrip Port Canaveral	Cruise Line Norwegian Cruise Line	Cruise Ship Norwegian New Build	Departs 5/10/25	Call For Pricing Call For Pricing See Itinerary
7-night Galapagos Inner Loop Cruise Roundtrip Isla Baltra	Cruise Line Celebrity Cruises	Cruise Ship Celebrity Flora	Departs 5/11/25	$9,525 From $9,525 See Itinerary
10-night From the Inca Empire to the Peruvian Amazon Cruise/Land Package Roundtrip Lima	Cruise Line Avalon Waterways	Cruise Ship Delfin III	Departs 5/11/25	$6,377 From $6,377 See Itinerary
6-night Wild Galapagos Escape Cruise Roundtrip Guayaquil	Cruise Line Lindblad Expeditions	Cruise Ship National Geographic Islander II	Departs 5/13/25	$8,757 From $8,757 See Itinerary
23-night Across the North Pacific Cruise Tokyo to San Francisco	Cruise Line Regent Seven Seas Cruises	Cruise Ship Seven Seas Mariner	Departs 5/14/25	$15,959 From $15,959 See Itinerary
10-night Magic of Colombia with 3 nights Medellin Cruise/Land Package Barranquilla to Cartagena	Cruise Line AmaWaterways	Cruise Ship AmaMagdalena	Departs 5/14/25	$4,774 From $4,774 See Itinerary
30-night Asia and Alaska Cruise Yokohama to Seattle	Cruise Line Cunard Line	Cruise Ship Queen Elizabeth	Departs 5/14/25	Call For Pricing Call For Pricing See Itinerary
10-night Peruvian Rivers and Rainforest Discovery Cruise/Land Package Roundtrip Lima	Cruise Line Uniworld River Cruises	Cruise Ship Aria Amazon	Departs 5/14/25	$12,999 From $12,999 See Itinerary
15-night Peruvian Amazon and Machu Picchu Exploration Cruise/Land Package Roundtrip Lima	Cruise Line Uniworld River Cruises	Cruise Ship Aria Amazon	Departs 5/14/25	$14,499 From $14,499 See Itinerary
7-night Magic of Colombia with 3 nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package Medellin to Panama City	Cruise Line AmaWaterways	Cruise Ship AmaMagdalena	Departs 5/14/25	Call For Pricing Call For Pricing See Itinerary

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Central & South America

Central & South America Cruises