Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,999 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/21/25
From
$5,924
4-night Baja Cruise From San Diego

Roundtrip San Diego

Cruise Line
Disney Cruise Line
Cruise Ship
Disney Wonder
Departs
4/21/25
From
$1,236
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise and 3 Nights in Panama City Post-Cruise Cruise/Land Package

Medellin to Panama City

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/21/25
 
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4-night Amazon Explorer Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
4/22/25
 
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16-night Trans-Pacific Cruise

Tokyo to Vancouver

Cruise Line
Silversea Cruises
Cruise Ship
Silver Nova
Departs
4/23/25
From
$7,700
12-night South Pacific Islands Expedition Cruise

Papeete to Lautoka

Cruise Line
Silversea Cruises
Cruise Ship
Silver Cloud Expedition
Departs
4/23/25
From
$15,100
7-night Ecuador and Its Galápagos Islands Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
4/23/25
From
$6,489
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package

Roundtrip Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
4/23/25
From
$8,906
10-night Peruvian Rivers and Rainforest Discovery Cruise/Land Package

Roundtrip Lima

Cruise Line
Uniworld River Cruises
Cruise Ship
Aria Amazon
Departs
4/23/25
From
$12,999
15-night Peruvian Amazon and Machu Picchu Exploration Cruise/Land Package

Roundtrip Lima

Cruise Line
Uniworld River Cruises
Cruise Ship
Aria Amazon
Departs
4/23/25
From
$14,499
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
4/24/25
From
$17,743
10-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
4/24/25
From
$9,727
11-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
4/24/25
From
$9,871
10-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
4/24/25
From
$8,307
11-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
4/24/25
From
$8,451
16-night Galápagos Southern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
4/24/25
From
$16,323
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/24/25
From
$4,499
7-night Wild Galapagos Escape Cruise

Roundtrip Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
4/24/25
From
$11,377
3-night Ensenada Cruise

Roundtrip Los Angeles

Cruise Line
Royal Caribbean International
Cruise Ship
Navigator of the Seas
Departs
4/25/25
10-night Wild Galapagos & Peru Escape Cruise

Lima to Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
4/25/25
From
$11,907
7-night Mexican Riviera Cruise From San Diego

Roundtrip San Diego

Cruise Line
Disney Cruise Line
Cruise Ship
Disney Wonder
Departs
4/25/25
From
$1,624
14-night West & East Galapagos Expedition Cruise

Roundtrip Puerto Ayora

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
4/25/25
 
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10-night Northern Gulf of California: Whales, Birds & Sealife Adventure Cruise

Roundtrip San Jose del Cabo (La Paz)

Cruise Line
UnCruise Adventures
Cruise Ship
Safari Voyager
Departs
4/25/25
 
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15-night Transpacific Cruise - Tokyo To Seattle

Tokyo to Seattle

Cruise Line
Royal Caribbean International
Cruise Ship
Anthem of the Seas
Departs
4/25/25
 
Call For Pricing