Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,999 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/21/25
|
From
$5,924
|
4-night Baja Cruise From San Diego
Roundtrip San Diego |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Wonder
|
Departs
4/21/25
|
From
$1,236
|
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise and 3 Nights in Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/21/25
|
Call For Pricing
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
4/22/25
|
Call For Pricing
|
16-night Trans-Pacific Cruise
Tokyo to Vancouver |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Nova
|
Departs
4/23/25
|
From
$7,700
|
12-night South Pacific Islands Expedition Cruise
Papeete to Lautoka |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Cloud Expedition
|
Departs
4/23/25
|
From
$15,100
|
7-night Ecuador and Its Galápagos Islands Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
4/23/25
|
From
$6,489
|
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
4/23/25
|
From
$8,906
|
10-night Peruvian Rivers and Rainforest Discovery Cruise/Land Package
Roundtrip Lima |
Cruise Line
Uniworld River Cruises
|
Cruise Ship
Aria Amazon
|
Departs
4/23/25
|
From
$12,999
|
15-night Peruvian Amazon and Machu Picchu Exploration Cruise/Land Package
Roundtrip Lima |
Cruise Line
Uniworld River Cruises
|
Cruise Ship
Aria Amazon
|
Departs
4/23/25
|
From
$14,499
|
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xpedition
|
Departs
4/24/25
|
From
$17,743
|
10-night Quito and Galápagos Northern Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xpedition
|
Departs
4/24/25
|
From
$9,727
|
11-night Quito and Galápagos Northern Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xpedition
|
Departs
4/24/25
|
From
$9,871
|
10-night Quito and Galápagos Southern Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xploration
|
Departs
4/24/25
|
From
$8,307
|
11-night Quito and Galápagos Southern Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xploration
|
Departs
4/24/25
|
From
$8,451
|
16-night Galápagos Southern Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Xploration
|
Departs
4/24/25
|
From
$16,323
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
4/24/25
|
From
$4,499
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
4/24/25
|
From
$11,377
|
3-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
4/25/25
|
From
$315
|
10-night Wild Galapagos & Peru Escape Cruise
Lima to Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
4/25/25
|
From
$11,907
|
7-night Mexican Riviera Cruise From San Diego
Roundtrip San Diego |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Wonder
|
Departs
4/25/25
|
From
$1,624
|
14-night West & East Galapagos Expedition Cruise
Roundtrip Puerto Ayora |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
4/25/25
|
Call For Pricing
|
10-night Northern Gulf of California: Whales, Birds & Sealife Adventure Cruise
Roundtrip San Jose del Cabo (La Paz) |
Cruise Line
UnCruise Adventures
|
Cruise Ship
Safari Voyager
|
Departs
4/25/25
|
Call For Pricing
|
15-night Transpacific Cruise - Tokyo To Seattle
Tokyo to Seattle |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Anthem of the Seas
|
Departs
4/25/25
|
Call For Pricing
|