Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,495 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
11-night Canal & Southern Caribbean Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Beyond
|
Departs
2/3/25
|
Call For Pricing
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
2/3/25
|
From
$441
|
|
14-night Caribbean East/West Adventurer Cruise
Roundtrip Port Canaveral |
Cruise Line
Princess Cruises
|
Cruise Ship
Caribbean Princess
|
Departs
2/3/25
|
Call For Pricing
|
|
19-night South America Cruise
Santiago (Valparaiso) to Buenos Aires |
Cruise Line
Crystal Cruises
|
Cruise Ship
Crystal Serenity
|
Departs
2/3/25
|
From
$11,700
|
|
9-night Antarctica Direct: Sail and Fly the Drake Passage Cruise/Land Package
Ushuaia to Puerto Natales, Chile |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
2/3/25
|
From
$13,707
|
|
10-night Secrets of Central America Cruise
Colon (Panama) to Puntarenas |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Bellot
|
Departs
2/3/25
|
Call For Pricing
|
|
16-night Antarctica And Patagonia: Legendary Ice And Epic Fjords Cruise
Buenos Aires to Punta Arenas |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
2/3/25
|
From
$24,262
|
|
81-night 2025 World Voyage Segment: San Francisco To Southampton
San Francisco to London (Southampton) |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Anne
|
Departs
2/4/25
|
From
$11,199
|
|
23-night 2025 World Voyage Segment: San Francisco To Sydney
San Francisco to Sydney |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Anne
|
Departs
2/4/25
|
From
$2,739
|
|
18-night 2025 World Voyage Segment: San Francisco To Auckland
San Francisco to Auckland |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Anne
|
Departs
2/4/25
|
Call For Pricing
|
|
6-night Galápagos Islands Expedition Cruise – Iconic Wildlife and Sublime Scenery
Roundtrip Quito |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Santa Cruz
|
Departs
2/4/25
|
Call For Pricing
|
|
10-night Galápagos Islands – Nine of the Best Isles Cruise/Land Package
Roundtrip Quito |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Santa Cruz
|
Departs
2/4/25
|
Call For Pricing
|
|
12-night Antarctic Explorer Cruise
Buenos Aires to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
2/4/25
|
From
$14,495
|
|
12-night Panama Canal With Costa Rica & Caribbean Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
2/4/25
|
Call For Pricing
|
|
6-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
2/4/25
|
From
$8,435
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
2/4/25
|
Call For Pricing
|
|
13-night Crossing the Circle: Southern Expedition
Roundtrip Ushuaia |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ocean Explorer
|
Departs
2/4/25
|
Call For Pricing
|
|
7-night Costa Rica And The Panama Canal Westbound Cruise
Panama City to San Jose (C.R.) |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Quest
|
Departs
2/4/25
|
From
$7,115
|
|
11-night Highlights of Antarctica Expedition
Roundtrip Buenos Aires |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Fridtjof Nansen
|
Departs
2/5/25
|
Call For Pricing
|
|
16-night Panama Canal - Ocean To Ocean Cruise
Ft. Lauderdale to Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Coral Princess
|
Departs
2/5/25
|
Call For Pricing
|
|
9-night A Journey To Pirate Lairs And Whale Sanctuaries
Roundtrip Miami |
Cruise Line
Explora Journeys
|
Cruise Ship
Explora I
|
Departs
2/5/25
|
From
$4,680
|
|
16-night An Extended Journey Of Caribbean Wonders, Waves & Whales
Roundtrip Miami |
Cruise Line
Explora Journeys
|
Cruise Ship
Explora I
|
Departs
2/5/25
|
From
$10,815
|
|
5-night Wild Baja California Escape: The Whales Of Magdalena Bay Cruise
Roundtrip Loreto |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Sea Bird
|
Departs
2/5/25
|
From
$4,756
|
|
11-night Caribbean Warmth Cruise
San Juan to Miami |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Navigator
|
Departs
2/6/25
|
Call For Pricing
|