Explore the wild side of South America with exciting cruises that take you through a continent filled with ancient ruins, cosmopolitan cities, and diverse landscapes. From the towering Andes to the lush rainforests and Patagonian grasslands, there is something for every traveler. An Antarctica cruise takes you across the Drake Passage, where you can witness the dramatic ice shelves and noticeable silence. Each cruise offers an overnight stay, giving you ample time to catch a tango show in Buenos Aires or soar through Panama's Soberanía National Park on an aerial tram. You can also marvel at the engineering wonders of the Panama Canal and discover quaint colonial towns along the golden coasts of Peru and Ecuador. Glide through the majestic Chilean fjords and the rugged Strait of Magellan and witness the world's largest gentoo penguin colony. Embark on a journey to the edge of the world with Holland America!
A lifetime of memories awaits, so connect with our Holland America experts at 1 (877) 734-6858 to reserve your stateroom today!
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| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
| 17-night Panama Canal & Inca Discovery Cruise Ft. Lauderdale to Santiago (San Antonio) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 11/14/24 | From $1,601 |
| 14-night South America Passage Cruise Santiago (San Antonio) to Buenos Aires | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 12/1/24 | From $1,421 |
| 14-night South America Passage Cruise Buenos Aires to Santiago (San Antonio) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 3/5/25 | From $1,511 |
| 17-night Inca & Panama Canal Discovery Cruise Santiago (San Antonio) to Ft. Lauderdale | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 3/19/25 | From $2,299 |
| 17-night Panama Canal & Inca Discovery Cruise Ft. Lauderdale to San Antonio (Santiago) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 11/17/25 | From $1,691 |
| 14-night South American Passage Cruise San Antonio (Santiago) to Buenos Aires | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 12/4/25 | From $1,556 |
| 14-night South American Passage Cruise Buenos Aires to San Antonio (Santiago) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 3/8/26 | From $1,646 |
| 14-night South America Passage Cruise Santiago (San Antonio) to Buenos Aires | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 2/19/25 | From $2,149 |
| 14-night South America Passage Cruise Santiago (San Antonio) to Buenos Aires | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 12/1/24 | From $1,421 |
| 14-night South America Passage Cruise Buenos Aires to Santiago (San Antonio) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 3/5/25 | From $1,511 |
| 14-night South American Passage Cruise San Antonio (Santiago) to Buenos Aires | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 12/4/25 | From $1,556 |
Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.