Cruise the legendary Mississippi
Experience the Mississippi River like never before with an all-inclusive river cruise from American Cruise Lines! Dive into the rich history and culture of the United States while savoring delicious regional cuisine, enjoying fantastic onboard music, and exploring historical landmarks through customized tours.
Special Offer: Save up to $1,000 + complimentary airfare on select sailings! Don’t miss this chance to create lasting memories on the iconic Mississippi!
Your River Cruise Always Includes:
Space is limited so don't miss out on this wonderful opportunity, contact our experts today at 1 (877) 734-6858!
Submit the form below or call us at 1 (877) 734-6858
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 5/16/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 5/27/25 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Louis (Alton) to St. Paul | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 7/11/25 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Nashville to Chattanooga | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 7/8/25 | Call For Pricing |
| 8-night Music Cities Cruise Memphis to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 7/22/25 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Louis (Alton) to St. Paul | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 7/25/25 | Call For Pricing |
| 15-night Grand Ohio River Cruise Pittsburgh to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 8/15/25 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Chattanooga to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 8/5/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 8/19/25 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Paul to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 9/5/25 | Call For Pricing |
| 15-night Grand Heartland Cruise St. Paul to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 9/12/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 10/3/25 | Call For Pricing |
| 8-night Music Cities Cruise Memphis to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 9/30/25 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 10/10/25 | Call For Pricing |
| 15-night Grand Heartland Cruise St. Paul to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 10/17/25 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 10/28/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 11/4/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 11/21/25 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 12/10/25 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 2/13/26 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 2/27/26 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 3/12/26 | Call For Pricing |
| 11-night Mississippi Explorer Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 3/18/26 | Call For Pricing |
| 11-night Mississippi Explorer Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 3/28/26 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 4/10/26 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 4/21/26 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Nashville to Chattanooga | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 4/28/26 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 5/15/26 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Paul to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 8/1/26 | Call For Pricing |
| 8-night Lower Mississippi River Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 7/14/26 | Call For Pricing |
| 11-night Mississippi River Gateway Cruise New Orleans to Louisville | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 6/22/26 | Call For Pricing |
| 8-night Music Cities Cruise Memphis to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 7/21/26 | Call For Pricing |
| 11-night Great Smoky Mountains National Park Cruise/Land Package Nashville to Knoxville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 9/8/26 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Nashville to Chattanooga | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 9/15/26 | Call For Pricing |
| 15-night Grand Heartland Cruise St. Paul to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 9/25/26 | Call For Pricing |
| 8-night Lower Mississippi River Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 9/25/26 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Paul to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 9/12/26 | Call For Pricing |
| 8-night Lower Mississippi River Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 11/3/26 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 2/18/27 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 3/3/27 | Call For Pricing |
| 8-night Lower Mississippi River Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 5/4/27 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 5/20/27 | Call For Pricing |
| 22-night Complete Mississippi River Cruise New Orleans to St. Paul | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 5/21/27 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Paul to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 7/3/27 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Chattanooga to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 8/3/27 | Call For Pricing |
| 15-night Grand Ohio River Cruise Pittsburgh to St. Louis | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 8/26/27 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 10/8/27 | Call For Pricing |
| 15-night Grand Heartland Cruise St. Paul to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 10/15/27 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 10/29/27 | Call For Pricing |
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 11/17/27 | Call For Pricing |
| 7-night Historic Mississippi River Cruise Roundtrip New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 12/2/27 | Call For Pricing |
| 8-night Lower Mississippi River Cruise New Orleans to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Melody | Departs 12/21/27 | Call For Pricing |
Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.