Mississippi River Cruises

Cruise the legendary Mississippi River with American Cruise Lines and get InsiderExtras you can't get anywhere else.

Experience the Mississippi River like never before on an all-inclusive river cruise. American Cruise Lines emphasizes the history and culture of the United States with delicious regional cuisine, amazing onboard music, and customized tours to historical landmarks.

Your river cruise always includes:

  • Complimentary gratuities
  • Complimentary internet
  • Beer and wine during lunch and dinner
  • Complimentary cocktail hour each evening
  • All onboard meals featuring locally sourced ingredients

PLUS, for a limited time, receive a complimentary bottle of wine when you reserve your cruise with us!

Contact CruiseInsider at 1 (877) 734-6858 to help you plan, perfect and save on your next journey.
Cruises Top
Cruises marked with are part of our Insider Advantage program which include free extras only available at CruiseInsider.
  Itinerary Cruise Line Ship Departing Extras Price
4-night Highlights of the Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 11/14/18
Roundtrip New Orleans
  From $2,995
4-night Highlights of the Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 11/10/18
Roundtrip New Orleans
  From $2,170
4-night Highlights of the Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 2/25/19
Roundtrip New Orleans
  From $1,870
4-night Highlights of the Mississippi River Cruise American Cruise Lines
America
America 7/6/19
Roundtrip New Orleans
  From $1,930
4-night Highlights of the Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/19/19
Roundtrip New Orleans
  From $1,970
4-night Highlights of the Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/1/19
Roundtrip New Orleans
  From $1,970
4-night Highlights of the Mississippi River Cruise American Cruise Lines
America
America 7/10/19
Roundtrip New Orleans
  From $2,130
4-night Highlights of the Mississippi River Cruise American Cruise Lines
America
America 10/22/19
Roundtrip New Orleans
  From $2,285
4-night Highlights of the Mississippi River Cruise American Cruise Lines
America
America 11/6/18
Roundtrip New Orleans
  From $2,450
7-night Cumberland River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 9/7/19
St. Louis to Nashville
  From $3,695
7-night Mississippi River Cruise American Cruise Lines
America
America 12/8/18
Roundtrip New Orleans
  From $3,205
7-night Mississippi River Cruise American Cruise Lines
America
America 2/23/19
Roundtrip New Orleans
  From $3,525
7-night Mississippi River Cruise American Cruise Lines
America
America 3/2/19
Roundtrip New Orleans
  From $3,225
7-night Cumberland River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 9/21/19
St. Louis to Nashville
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 12/1/18
Memphis to New Orleans
  From $3,270
7-night Cumberland River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 9/14/19
Nashville to St. Louis
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 11/24/18
New Orleans to Memphis
  From $3,270
7-night Mississippi River Cruise American Cruise Lines
America
America 3/9/19
Roundtrip New Orleans
  From $3,525
7-night Cumberland River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 9/8/18
St. Louis to Nashville
  From $4,845
7-night Mississippi River Cruise American Cruise Lines
America
America 12/12/19
Roundtrip New Orleans
  From $3,525
7-night New Orleans to New Orleans Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/23/19
Roundtrip New Orleans
  From $3,525
7-night New Orleans to New Orleans Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 12/7/19
Roundtrip New Orleans
  From $3,525
7-night Lower Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/12/19
Memphis to New Orleans
  From $3,595
7-night Mississippi River Cruise American Cruise Lines
American Song
American Song 12/1/18
Roundtrip New Orleans
  From $3,705
7-night Mississippi River Cruise American Cruise Lines
American Song
American Song 12/8/18
Roundtrip New Orleans
  From $3,705
7-night Mississippi River Cruise American Cruise Lines
American Song
American Song 12/22/18
Roundtrip New Orleans
  From $3,705
10-night Ohio River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 6/25/19
St. Louis to Pittsburgh
  From $4,510
10-night Ohio River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 6/23/20
St. Louis to Pittsburgh
  From $5,310
10-night Ohio River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 7/7/18
St. Louis to Pittsburgh
  From $5,135
7-night Mississippi River Cruise American Cruise Lines
America
America 3/16/19
Roundtrip New Orleans
  From $3,705
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 11/30/19
Memphis to New Orleans
  From $3,770
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 12/28/19
Memphis to New Orleans
  From $3,770
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 11/23/19
New Orleans to Memphis
  From $3,770
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 12/20/19
New Orleans to Memphis
  From $3,770
7-night Lower Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 6/8/19
Memphis to New Orleans
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/30/19
New Orleans to Memphis
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 6/1/19
New Orleans to Memphis
  From $3,795
7-night Upper Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 8/31/19
St. Paul to St. Louis
  From $3,495
7-night Upper Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 8/24/19
St. Louis to St. Paul
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 3/30/19
Memphis to New Orleans
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 6/1/19
Memphis to New Orleans
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 6/15/19
Memphis to New Orleans
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 6/29/19
Memphis to New Orleans
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
America
America 6/22/19
New Orleans to Memphis
  From $3,795
7-night Lower Mississippi River Cruise American Cruise Lines
Queen of the Mississippi
Queen of the Mississippi 3/5/19
New Orleans to Memphis
  From $3,795
7-night New Orleans to New Orleans Cruise American Cruise Lines
American Harmony
American Harmony 11/15/19
Roundtrip New Orleans
  From $3,840
7-night New Orleans to New Orleans Cruise American Cruise Lines
American Harmony
American Harmony 11/22/19
Roundtrip New Orleans
  From $3,640
Looking for assistance? Speak to an expert at  1 (877) 734-6858  and we'll help find the perfect cruise that fits your travel needs.

Terms and Conditions: Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.

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