Explore ancient glories, modern delights and stunning beauty on an unforgettable Mediterranean cruise vacation. From Rome, Italy’s legendary Colosseum to trend-setting Barcelona, Spain; every day is filled with iconic cityscapes and landmarks, flaxen beaches, and remote coastal villages. Choose from an array of carefully curated itineraries, destination ports, and breathtaking destinations to make your luxury Mediterranean cruise dream a reality.
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| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
| 11-night Mediterranean Romance Cruise Athens (Piraeus) to Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 6/1/24 | From $1,899 |
| 12-night Mediterranean Empires Cruise Athens (Piraeus) to Trieste | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 6/23/24 | From $2,349 |
| 9-night Adriatic & Italian Splendors Cruise Trieste to Rome (Civitavecchia) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 7/5/24 | From $1,749 |
| 10-night Italian Coast & Greek Wonders Cruise Rome (Civitavecchia) to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 7/28/24 | From $1,899 |
| 11-night Ancient Kingdoms & Turkish Delight Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 8/7/24 | From $1,599 |
| 18-night Malta & Mediterranean Romance Cruise Rome (Civitavecchia) to Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 9/1/24 | From $3,239 |
| 14-night Iberian Adventure Cruise Amsterdam to Rome (Civitavecchia) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 9/7/24 | From $2,569 |
| 14-night Ancient Mysteries & Egypt Cruise Rome (Civitavecchia) to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 9/21/24 | From $2,069 |
| 14-night Ancient Mysteries & Egypt Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 10/5/24 | From $2,199 |
| 10-night Greece & Adriatic Antiquities Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 10/10/24 | From $1,574 |
| 14-night Turkey & Greek Isles Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 10/19/24 | From $1,899 |
| 14-night Spanish Farewell Cruise Barcelona to Ft. Lauderdale | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 10/31/24 | From $1,899 |
| 11-night Western Mediterranean Medley Cruise Roundtrip Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 5/3/25 | From $1,682 |
| 10-night Malta, Sicily & Aegean Jewels: Naples & Hidden Gems Cruise Civitavecchia to Piraeus (Athens) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 5/29/25 | From $1,457 |
| 11-night Athens & Adriatic Allure: Mykonos Evening Stay Cruise Athens (Piraeus) to Venice (Trieste) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 6/8/25 | From $1,637 |
| 10-night Around Italy's Boot: Palermo Cruise Trieste (Venice) to Civitavecchia (Rome) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 6/19/25 | From $1,457 |
| 7-night Western Mediterranean Medley Cruise Lisbon to Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 7/13/25 | From $1,052 |
| 10-night Adriatic Antiquities: Dalmatian Coast Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 7/30/25 | From $1,457 |
| 11-night Around Italy's Boot: Cote D'Azur Cruise Trieste (Venice) to Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 8/30/25 | From $1,682 |
| 14-night Eastern Mediterranean Cruise: Egypt & Istanbul Overnight Barcelona to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 9/20/25 | From $2,087 |
| 14-Day Malta, Sicily & Aegean Jewels: Istanbul Overnight Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 10/4/25 | From $2,969 |
| 14-night Eastern Mediterranean Cruise: Tel Aviv & Rhodes Overnights Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 10/18/25 | From $2,087 |
| 11-night Traversing the Mediterranean: Naples & Corsica Cruise Athens (Piraeus) to Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 10/22/25 | From $1,727 |
| 7-night Malta & Aegean Jewels Cruise Rome (Civitavecchia) to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 9/1/24 | From $1,099 |
| 14-night Adriatic Gems & Aegean Jewels Cruise Roundtrip Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 8/25/24 | From $2,229 |
| 10-night Mediterranean Odyssey Cruise Barcelona to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 9/19/24 | From $2,599 |
| 10-Day Western Mediterranean Medley: Malta Overnight Roundtrip Barcelona | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 5/14/25 | From $2,299 |
| 14-Day Traversing The Mediterranean: Barcelona Overnight Rome (Civitavecchia) to Lisbon | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 6/29/25 | From $2,969 |
| 10-Day Traversing The Mediterranean: Riviera Retreat Barcelona to Athens (Piraeus) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 7/20/25 | From $2,149 |
| 10-Day Athens & Adriatic Allure: Dubrovnik Stay Piraeus (Athens) to Trieste (Venice) | Cruise Line Holland America Line | Cruise Ship Oosterdam | Departs 8/20/25 | From $2,249 |
| 14-Day Around The Iberian Peninsula London (Dover) to Barcelona | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 9/6/25 | From $2,669 |
| 14-Day Adriatic Antiquities: Strait Of Messina & Stromboli Athens (Piraeus) to Rome (Civitavecchia) | Cruise Line Holland America Line | Cruise Ship Nieuw Statendam | Departs 11/1/25 | From $2,969 |
Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.