Discover the heart of American cruising with American Cruise Lines, where rich history intertwines with the beauty of our nation's waterways. The American made, intimate ships offer a unique blend of luxury and heritage, inviting you to explore the hidden gems of the United States while being treated to well-designed enrichment programs on board and ashore, as well as personalized exploration led by engaging local guides. American Cruise Lines is 100% American. Every port of call is in the U.S., every crewmember is American, and the story we tell along the way is about America. Each day is an opportunity to explore a new destination close to home. American Cruise Lines delivers culture, history, and enlightenment.
Your river cruise always includes:
So where will you explore first? This is small ship cruising done perfectly so these sailings sell out quickly. Select sailings and some restrictions apply so contact our experts today at 1 (877) 734-6858 to learn more.
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| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
| 8-night Lower Mississippi River Cruise Memphis to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 5/13/25 | Call For Pricing |
| 7-night Chesapeake Bay Cruise Roundtrip Baltimore, MD | Cruise Line American Cruise Lines | Cruise Ship American Independence | Departs 5/17/25 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Chattanooga to Nashville | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 5/20/25 | Call For Pricing |
| 8-night Maine Coast and Harbors Cruise Bangor, ME to Portland, ME | Cruise Line American Cruise Lines | Cruise Ship American Glory | Departs 6/16/25 | Call For Pricing |
| 11-night Alaskan Explorer Cruise Juneau to Seattle | Cruise Line American Cruise Lines | Cruise Ship American Constitution | Departs 6/16/25 | Call For Pricing |
| 8-night Music Cities Cruise Nashville to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 6/17/25 | Call For Pricing |
| 14-night National Parks & Legendary Rivers Cruise/Land Package Jackson to Portland | Cruise Line American Cruise Lines | Cruise Ship American Harmony | Departs 6/21/25 | Call For Pricing |
| 8-night Maine Coast and Harbors Cruise Portland, ME to Bangor, ME | Cruise Line American Cruise Lines | Cruise Ship American Glory | Departs 6/23/25 | Call For Pricing |
| 8-night Maine Coast and Harbors Cruise Bangor, ME to Portland, ME | Cruise Line American Cruise Lines | Cruise Ship American Glory | Departs 6/16/25 | Call For Pricing |
| 11-night Alaskan Explorer Cruise Juneau to Seattle | Cruise Line American Cruise Lines | Cruise Ship American Constitution | Departs 6/16/25 | Call For Pricing |
| 8-night Music Cities Cruise Nashville to Memphis | Cruise Line American Cruise Lines | Cruise Ship American Splendor | Departs 6/17/25 | Call For Pricing |
| 14-night National Parks & Legendary Rivers Cruise/Land Package Jackson to Portland | Cruise Line American Cruise Lines | Cruise Ship American Harmony | Departs 6/21/25 | Call For Pricing |
| 8-night Maine Coast and Harbors Cruise Portland, ME to Bangor, ME | Cruise Line American Cruise Lines | Cruise Ship American Glory | Departs 6/23/25 | Call For Pricing |
| 15-night National Parks & Legendary Rivers Cruise/Land Package Portland to Jackson | Cruise Line American Cruise Lines | Cruise Ship American Harmony | Departs 9/12/25 | Call For Pricing |
| 15-night Grand Heartland Cruise St. Paul to New Orleans | Cruise Line American Cruise Lines | Cruise Ship American Heritage | Departs 9/12/25 | Call For Pricing |
| 10-night American Revolution Cruise Roundtrip Washington, DC | Cruise Line American Cruise Lines | Cruise Ship American Legend | Departs 4/22/26 | Call For Pricing |
| 10-night American Revolution Cruise Roundtrip Washington, DC | Cruise Line American Cruise Lines | Cruise Ship American Legend | Departs 5/22/26 | Call For Pricing |
| 7-night Cape Codder Cruise Roundtrip Boston | Cruise Line American Cruise Lines | Cruise Ship American Glory | Departs 5/25/26 | Call For Pricing |
| 8-night Columbia and Snake Rivers Cruise Portland to Clarkston | Cruise Line American Cruise Lines | Cruise Ship American Jazz | Departs 5/29/26 | Call For Pricing |
| 14-night National Parks & Legendary Rivers Cruise/Land Package Jackson to Portland | Cruise Line American Cruise Lines | Cruise Ship American Song | Departs 6/24/26 | Call For Pricing |
| 15-night National Parks & Legendary Rivers Cruise/Land Package Portland to Jackson | Cruise Line American Cruise Lines | Cruise Ship American Jazz | Departs 6/26/26 | Call For Pricing |
| 8-night The Tennessee Rivers Cruise Nashville to Chattanooga | Cruise Line American Cruise Lines | Cruise Ship American Symphony | Departs 7/21/26 | Call For Pricing |
| 8-night Upper Mississippi River Cruise St. Louis to St. Paul | Cruise Line American Cruise Lines | Cruise Ship American Serenade | Departs 7/24/26 | Call For Pricing |
| 15-night National Parks & Legendary Rivers Cruise/Land Package Portland to Jackson | Cruise Line American Cruise Lines | Cruise Ship American Jazz | Departs 7/24/26 | Call For Pricing |
| 7-night Puget Sound and San Juan Islands Cruise Roundtrip Seattle | Cruise Line American Cruise Lines | Cruise Ship American Spirit | Departs 7/25/26 | Call For Pricing |
| 8-night Columbia and Snake Rivers Cruise Portland to Clarkston | Cruise Line American Cruise Lines | Cruise Ship American Song | Departs 8/18/26 | Call For Pricing |
Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.