Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,947 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

11-night Classic Panama Canal Voyage

Panama City to Miami

Cruise Line
Oceania Cruises
Cruise Ship
Sirena
Departs
2/18/25
From
$3,599
17-night South America and the Chilean Fjords Cruise

Buenos Aires to Santiago (Valparaiso)

Cruise Line
Viking Cruises
Cruise Ship
Viking Jupiter (Ocean)
Departs
2/18/25
From
$6,999
11-night Journey to Antarctica – The White Continent Cruise

Roundtrip Santiago

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Resolution
Departs
2/18/25
From
$18,536
6-night Galápagos Islands Expedition Cruise – Iconic Wildlife and Sublime Scenery

Roundtrip Quito

Cruise Line
Hurtigruten
Cruise Ship
MS Santa Cruz
Departs
2/18/25
From
$5,225
10-night Galápagos Islands – Nine of the Best Isles Cruise/Land Package

Roundtrip Quito

Cruise Line
Hurtigruten
Cruise Ship
MS Santa Cruz
Departs
2/18/25
From
$7,933
6-night Wild Galapagos Escape Cruise

Roundtrip Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
2/18/25
From
$10,241
10-night Antarctic Explorer: Discovering the 7th Continent Expedition

Roundtrip Ushuaia

Cruise Line
Quark Expeditions
Cruise Ship
World Explorer
Departs
2/18/25
 
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18-night Iridescent Isles & Inlets Voyage

Roundtrip Miami

Cruise Line
Oceania Cruises
Cruise Ship
Vista
Departs
2/19/25
From
$7,199
14-night South America Passage Cruise

Santiago (San Antonio) to Buenos Aires

Cruise Line
Holland America Line
Cruise Ship
Oosterdam
Departs
2/19/25
From
$2,149
10-night Southern Caribbean Seafarer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Holland America Line
Cruise Ship
Eurodam
Departs
2/19/25
From
$1,142
11-night Antarctic Explorer – Discovering the 7th Continent Expedition

Roundtrip Buenos Aires

Cruise Line
Quark Expeditions
Cruise Ship
Ultramarine
Departs
2/19/25
 
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21-night Southern Caribbean Seafarer / Eastern Wayfarer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Holland America Line
Cruise Ship
Eurodam
Departs
2/19/25
From
$3,509
10-night Magic of Colombia with 3 nights Medellin Cruise/Land Package

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
2/19/25
From
$5,224
10-night Peruvian Rivers and Rainforest Discovery Cruise/Land Package

Roundtrip Lima

Cruise Line
Uniworld River Cruises
Cruise Ship
Aria Amazon
Departs
2/19/25
From
$12,999
15-night Peruvian Amazon and Machu Picchu Exploration Cruise/Land Package

Roundtrip Lima

Cruise Line
Uniworld River Cruises
Cruise Ship
Aria Amazon
Departs
2/19/25
From
$14,499
21-night Antarctica, South Georgia, and the Falkland Islands Cruise/Land Package

Roundtrip Buenos Aires

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Endurance
Departs
2/20/25
From
$34,693
16-night Galápagos Southern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
2/20/25
From
$17,647
10-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
2/20/25
From
$9,631
11-night Quito and Galápagos Southern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
2/20/25
From
$9,775
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
2/20/25
From
$17,123
8-night Cruising the Galápagos Islands Cruise/Land Package

Roundtrip Guayaquil

Cruise Line
Tauck Cruises
Cruise Ship
Isabela II
Departs
2/20/25
From
$9,590
68-night Longitudinal World Cruise V

Buenos Aires to Milwaukee

Cruise Line
Viking Cruises
Cruise Ship
Viking Octantis
Departs
2/20/25
From
$52,995
47-night Antarctica, Chile & the Americas Cruise

Buenos Aires to Ft. Lauderdale

Cruise Line
Viking Cruises
Cruise Ship
Viking Octantis
Departs
2/20/25
From
$38,885
12-night Panama Canal Cruise

Miami to Panama City

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Jade
Departs
2/20/25
 
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