Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,914 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

20-night Panoramic Panama Canal - 2025 World Cruise Segment

San Diego to New York City

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
7/3/25
From
$5,299
16-night Galápagos Northern Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
7/3/25
From
$19,471
10-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
7/3/25
From
$11,455
11-night Quito and Galápagos Northern Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
7/3/25
From
$11,599
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
7/3/25
From
$4,349
10-night Quito and Galápagos Inner Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
7/4/25
From
$11,520
11-night Quito and Galápagos Inner Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
7/4/25
From
$11,640
16-night Galápagos Inner Loop and Machu Picchu Cruise/Land Package

Quito to Lima

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
7/4/25
From
$18,200
10-night Caribbean with Bermuda Overnight Cruise

Roundtrip New York City

Cruise Line
Princess Cruises
Cruise Ship
Island Princess
Departs
7/4/25
 
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12-night From the Inca Empire to the Peruvian Amazon with the Nazca Lines Cruise/Land Package

Roundtrip Lima

Cruise Line
Avalon Waterways
Cruise Ship
Delfin III
Departs
7/4/25
From
$7,397
10-night Wild Galapagos & Peru Escape Cruise

Lima to Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
7/4/25
From
$12,589
7-night West Galapagos Expedition Cruise

Puerto Ayora to Baltra Island

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
7/4/25
 
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14-night West & East Galapagos Expedition Cruise

Roundtrip Puerto Ayora

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
7/4/25
 
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9-night Eastern Caribbean & Perfect Day Cruise

Roundtrip Cape Liberty Cruise Port (Bayonne, NJ)

Cruise Line
Royal Caribbean International
Cruise Ship
Symphony of the Seas
Departs
7/4/25
From
$1,262
7-night Cabo, Vallarta & Mazatlan Cruise

Roundtrip Los Angeles

Cruise Line
Royal Caribbean International
Cruise Ship
Navigator of the Seas
Departs
7/4/25
7-night Galapagos Northern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
7/5/25
From
$9,055
7-night Wonders of Colombia Cruise

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
7/5/25
From
$3,449
14-night Caribbean East/West Adventurer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
7/5/25
 
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7-night Galapagos Southern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
7/5/25
From
$6,847
10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package

Cartagena to Barranquilla

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
7/5/25
 
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7-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
7/5/25
From
$12,200
7-night Eastern Caribbean Cruise

Roundtrip Port Canaveral

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian New Build
Departs
7/5/25
 
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3-night Amazon Discovery Cruise

Iquitos to Nauta

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
7/5/25
 
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7-night Amazon Expeditions Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
7/5/25
 
Call For Pricing