Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,932 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
6/21/25
|
Call For Pricing
|
|
7-night Galápagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
6/21/25
|
From
$40,550
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
6/21/25
|
Call For Pricing
|
|
9-night Upper Amazon Aboard The Delfin II Cruise
Roundtrip Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
Delfin II
|
Departs
6/21/25
|
From
$9,145
|
|
7-night Galapagos Inner Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
6/22/25
|
From
$10,708
|
|
10-night Magic of Colombia with 3 nights Medellin Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
6/22/25
|
Call For Pricing
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
6/22/25
|
Call For Pricing
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
6/23/25
|
From
$832
|
|
6-night Wild Galapagos Escape: A 7-Day Voyage
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
6/24/25
|
From
$9,821
|
|
7-night Galápagos: Wildlife Wonderland Cruise/Land Package
Quito to Guayaquil |
Cruise Line
Tauck Cruises
|
Cruise Ship
Santa Cruz II
|
Departs
6/24/25
|
From
$8,490
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
6/24/25
|
Call For Pricing
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
6/25/25
|
Call For Pricing
|
|
10-night Magic of Colombia with 3 nights Medellin Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
6/25/25
|
Call For Pricing
|
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
6/25/25
|
Call For Pricing
|
|
7-night Magic of Colombia with 3 nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
6/25/25
|
Call For Pricing
|
|
6-night Cabo Overnight And Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Ovation of the Seas
|
Departs
6/25/25
|
From
$1,182
|
|
16-night Galápagos Outer Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
6/27/25
|
Call For Pricing
|
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
6/27/25
|
Call For Pricing
|
|
7-night East Galapagos Expedition Cruise
Baltra Island to Puerto Ayora |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
6/27/25
|
Call For Pricing
|
|
14-night East & West Galapagos Expedition Cruise
Roundtrip Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
6/27/25
|
Call For Pricing
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
6/27/25
|
From
$15,268
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
6/27/25
|
From
$9,230
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
6/27/25
|
From
$9,179
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
6/27/25
|
From
$9,415
|