Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,941 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
68-night Kimberley Expedition & Remote Islands Of The Pacific Cruise
Broome to Santiago (San Antonio) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
8/24/25
|
From
$42,994
|
120-night Global Wanderlust Voyage
San Diego to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
3/7/26
|
From
$41,999
|
22-night In-Depth Antarctica, Falklands, and South Georgia Expedition
Roundtrip Santiago |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Fram
|
Departs
1/11/25
|
From
$41,426
|
155-Night Azamara World Voyage
San Diego to London (Southampton) |
Cruise Line
Azamara
|
Cruise Ship
Azamara Onward
|
Departs
1/6/25
|
From
$41,000
|
155-night Azamara World Voyage
Miami to Barcelona |
Cruise Line
Azamara
|
Cruise Ship
Azamara Onward
|
Departs
1/6/26
|
From
$41,000
|
47-night Antarctica, Chile & the Americas Cruise
Buenos Aires to Ft. Lauderdale |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
2/20/25
|
From
$38,885
|
21-night Antarctica, South Georgia, and the Falkland Islands Cruise/Land Package
Roundtrip Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endurance
|
Departs
10/23/24
|
From
$38,153
|
46-night The Americas, Chile & Antarctica Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
10/13/25
|
From
$37,885
|
63-night Between the Poles - Our Epic Global Expedition Cruise
Edmonton to Santiago |
Cruise Line
Hurtigruten
|
Cruise Ship
MS Fram
|
Departs
9/8/24
|
From
$37,231
|
90-night Ultimate Snowbird Paradise Voyage
Roundtrip Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
1/8/25
|
From
$36,899
|
18-night Antarctica Cruise
Roundtrip Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Endeavour
|
Departs
1/6/26
|
From
$36,645
|
22-night Transpacific Cruise
Los Angeles to Papeete |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Shadow
|
Departs
1/4/25
|
From
$36,600
|
57-night New Guinea To The Remote Islands Of The Pacific Cruise
Darwin to Santiago (San Antonio) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
9/4/25
|
From
$36,054
|
77-night Australia, Asia & Alaska Cruise
Sydney to Vancouver |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
3/30/26
|
From
$35,995
|
15-night Antarctica Expedition Cruise
Port Williams to King George Island |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Endeavour
|
Departs
12/22/24
|
From
$35,500
|
52-night History, Culture & Isles Of Oceania Cruise
Santiago (San Antonio) to Darwin |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
3/18/25
|
From
$34,734
|
21-night Antarctica, South Georgia, and the Falkland Islands Cruise/Land Package
Roundtrip Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endurance
|
Departs
1/11/25
|
From
$34,693
|
21-night Antarctica, South Georgia, and the Falkland Islands Cruise/Land Package
Roundtrip Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endurance
|
Departs
2/20/25
|
From
$34,693
|
40-night The Americas & Antarctic Explorer Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
10/22/24
|
From
$33,485
|
15-night Antarctica Expedition Cruise
King George Island to Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Endeavour
|
Departs
1/6/25
|
From
$32,900
|
40-night The Americas & Antarctic Explorer Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
10/6/25
|
From
$32,485
|
41-night The Americas & Antarctic Explorer Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
10/25/24
|
From
$32,185
|
19-night A Journey from Nome to Tokyo – Ring of Fire to Ainu Culture Cruise/Land Package
Anchorage to Tokyo |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
8/13/24
|
From
$31,590
|
21-night Antarctica, South Georgia & Falkland Holiday Cruise
Roundtrip Buenos Aires |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
12/16/25
|
From
$29,987
|