Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
4,912 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
86-night From The Arctic To Antarctica Cruise
Nuuk to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
9/3/25
|
From
$74,995
|
86-night From The Arctic To Antarctica Cruise
Nuuk to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
9/17/26
|
From
$75,995
|
85-night South America Discovery From Hamburg Cruise
Roundtrip Hamburg |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Victoria
|
Departs
1/4/25
|
Call For Pricing
|
81-night San Francisco To Southampton Cruise
San Francisco to London (Southampton) |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Anne
|
Departs
2/4/25
|
From
$11,199
|
79-night Ultimate Pacific Traveler Voyage
Los Angeles to Sydney |
Cruise Line
Oceania Cruises
|
Cruise Ship
Regatta
|
Departs
10/3/24
|
From
$19,799
|
79-night Australia, Asia & Alaska Cruise
Vancouver to Sydney |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
9/14/25
|
Call For Pricing
|
79-night Circle South America Grand Voyage
Roundtrip Miami |
Cruise Line
Azamara
|
Cruise Ship
Azamara Quest
|
Departs
1/6/26
|
From
$18,389
|
78-night Australia, Asia, and Alaska Cruise
Vancouver to Sydney |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
9/11/24
|
From
$41,395
|
78-night South America Discovery Cruise
Roundtrip London (Southampton) |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Victoria
|
Departs
1/9/25
|
Call For Pricing
|
78-night Australia, Asia, and Alaska Cruise
Sydney to Vancouver |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
3/21/25
|
Call For Pricing
|
77-night Tale of Three Continents - 2025 World Cruise Segment
Miami to Singapore |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
1/5/25
|
Call For Pricing
|
77-night Spanning The Americas Voyage - 2026 World Cruise Segment
Los Angeles to San Diego |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
12/20/25
|
From
$28,749
|
77-night Australia, Asia & Alaska Cruise
Sydney to Vancouver |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Orion (Ocean)
|
Departs
3/30/26
|
From
$35,995
|
75-night Grand South Pacific Expedition Cruise
Perth (Fremantle) to Santiago (Valparaiso) |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Cloud Expedition
|
Departs
8/25/24
|
Call For Pricing
|
74-night Grand South Pacific Expedition Cruise
Perth (Fremantle) to Santiago (Valparaiso) |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Cloud Expedition
|
Departs
8/25/24
|
Call For Pricing
|
74-night Australia to South America Cruise
Perth (Fremantle) to Santiago (Valparaiso) |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Cloud Expedition
|
Departs
8/20/25
|
Call For Pricing
|
74-night Southern Seas Saga Voyage
Los Angeles to Hong Kong |
Cruise Line
Oceania Cruises
|
Cruise Ship
Regatta
|
Departs
11/26/25
|
From
$22,199
|
71-night Grand South America Voyage
Roundtrip Ft. Lauderdale |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Ray
|
Departs
1/20/25
|
Call For Pricing
|
70-night Longitudinal World Cruise II
Duluth to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
9/26/24
|
Call For Pricing
|
68-night Longitudinal World Cruise V
Buenos Aires to Milwaukee |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
2/20/25
|
From
$57,495
|
68-night Kimberley Expedition & Remote Islands Of The Pacific Cruise
Broome to Santiago (San Antonio) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
8/24/25
|
From
$42,994
|
68-night Longitudinal World Cruise VI
Buenos Aires to Milwaukee |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
2/24/26
|
From
$52,995
|
66-night World Cruise Segment - Panama Canal, South Pacific & Indian Ocean Cruise
Ft. Lauderdale to Dubai |
Cruise Line
Princess Cruises
|
Cruise Ship
Island Princess
|
Departs
1/5/25
|
Call For Pricing
|
65-night Grand Pacific Hemispheres Voyage
Los Angeles to Auckland |
Cruise Line
Oceania Cruises
|
Cruise Ship
Regatta
|
Departs
10/3/24
|
Call For Pricing
|