Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,922 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
12-night Amazon Delta & Coast Of Brazil Cruise
Manaus (Amazon River) to Rio de Janeiro |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Venture
|
Departs
10/30/25
|
From
$9,499
|
|
12-night Chilean Fjords & Scenic Shores Cruise
Santiago (Valparaiso) to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
10/30/25
|
From
$7,995
|
|
13-night The Emperor Penguins Of Weddell Sea Cruise/Land Package
Roundtrip Santiago |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Commandant Charcot
|
Departs
10/30/25
|
Call For Pricing
|
|
10-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/31/25
|
Call For Pricing
|
|
11-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/31/25
|
Call For Pricing
|
|
16-night Galápagos Outer Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/31/25
|
Call For Pricing
|
|
8-night Eastern Caribbean Cruise
Roundtrip Port Canaveral |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Adventure of the Seas
|
Departs
10/31/25
|
From
$766
|
|
7-night East Galapagos Expedition Cruise
Baltra Island to Puerto Ayora |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/31/25
|
Call For Pricing
|
|
14-night East & West Galapagos Expedition Cruise
Roundtrip Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/31/25
|
Call For Pricing
|
|
7-night Wonders of Colombia with 3 Nights in Medellin and 2 Nights in Cartagena Pre-Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/31/25
|
Call For Pricing
|
|
7-night Wonders of Colombia with 3 nights in Medellin, 2 nights in Cartagena Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/31/25
|
Call For Pricing
|
|
3-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/31/25
|
From
$363
|
|
4-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/31/25
|
From
$399
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/31/25
|
From
$9,940
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/31/25
|
From
$15,978
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/31/25
|
From
$13,196
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/31/25
|
From
$7,158
|
|
8-night Southern Caribbean & Perfect Day Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Oasis of the Seas
|
Departs
11/1/25
|
From
$1,127
|
|
7-night Mexican Riviera Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Royal Princess
|
Departs
11/1/25
|
From
$1,118
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
11/1/25
|
Call For Pricing
|
|
7-night Classic California Coast Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
11/1/25
|
From
$1,154
|
|
14-night Classic California Coast And Mexican Riviera Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
11/1/25
|
From
$1,805
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
11/1/25
|
From
$3,339
|
|
28-night Panama Canal & Eastern Caribbean Cruise
San Diego to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Koningsdam
|
Departs
11/1/25
|
From
$4,474
|