Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,916 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Galapagos Inner Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/26/25
|
From
$13,120
|
|
10-night From the Inca Empire to the Peruvian Amazon Cruise
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/26/25
|
From
$6,377
|
|
7-night Western Caribbean With Mexico Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
10/26/25
|
From
$1,018
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/26/25
|
From
$6,762
|
|
10-night Antarctica Cruise
Roundtrip Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Wind
|
Departs
10/26/25
|
Call For Pricing
|
|
12-night Panama Canal Discovery: Costa Rica & Greater Antilles Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Rotterdam
|
Departs
10/26/25
|
From
$1,782
|
|
21-night Panama Canal & Southern Caribbean: Abc Islands Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Rotterdam
|
Departs
10/26/25
|
From
$3,294
|
|
17-night From The Inca Empire To The Peruvian Amazon With Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/26/25
|
Call For Pricing
|
|
7-night Panama And Colombia Westbound Cruise: Exploring The Caribbean Coast
Cartagena to Panama City |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Quest
|
Departs
10/26/25
|
From
$5,448
|
|
41-night Caribbean & Amazon Icons Voyage
Boston to Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Insignia
|
Departs
10/27/25
|
From
$9,199
|
|
16-night Panama Canal - Ocean To Ocean Cruise
Los Angeles to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Coral Princess
|
Departs
10/28/25
|
From
$1,858
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/28/25
|
Call For Pricing
|
|
9-night Western Caribbean Cruise
Roundtrip Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
10/28/25
|
From
$1,053
|
|
21-night Caribbean Cruise
Roundtrip Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
10/28/25
|
From
$2,320
|
|
3-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/28/25
|
From
$312
|
|
14-night The Best of Chilean Fjords Cruise
Santiago(Valparaiso) to Ushuaia |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Lyrial
|
Departs
10/28/25
|
From
$11,060
|
|
21-night Antarctica, South Georgia, And The Falklands Cruise
Roundtrip Santiago |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
10/28/25
|
From
$24,902
|
|
4-night Eastern Caribbean Cruise
Roundtrip Miami |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Symphony of the Seas
|
Departs
10/29/25
|
From
$467
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/29/25
|
From
$3,339
|
|
7-night Magic of Colombia with 3 Nights Panama City Post-Cruise Cruise/Land Package
Barranquilla to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/29/25
|
Call For Pricing
|
|
7-night Magic Of Colombia With 3-nights Medellín Pre Cruise Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/29/25
|
From
$4,764
|
|
13-night The Emperor Penguins Of Weddell Sea Cruise/Land Package
Roundtrip Santiago |
Cruise Line
Ponant Cruises
|
Cruise Ship
Le Commandant Charcot
|
Departs
10/30/25
|
Call For Pricing
|
|
21-night Antarctica, South Georgia, And The Falklands Cruise
Roundtrip Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endurance
|
Departs
10/30/25
|
From
$28,015
|
|
17-night Snow Hill To The Peninsula: Emperor Penguins And The 7Th Continent
Roundtrip Buenos Aires |
Cruise Line
Quark Expeditions
|
Cruise Ship
Ultramarine
|
Departs
10/30/25
|
Call For Pricing
|