Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,916 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
16-night Galápagos Inner Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/24/25
|
Call For Pricing
|
|
12-night From the Inca Empire to the Peruvian Amazon with the Nazca Lines Cruise/Land Package
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/24/25
|
From
$7,477
|
|
7-night Cabo, Vallarta & Mazatlan Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/24/25
|
From
$662
|
|
19-night From The Inca Empire To The Peruvian Amazon With The Nazca Lines & Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/24/25
|
Call For Pricing
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
10/24/25
|
From
$13,686
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
10/24/25
|
From
$7,648
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/24/25
|
From
$13,990
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/24/25
|
From
$13,196
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/24/25
|
From
$7,158
|
|
7-night Galapagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
10/25/25
|
From
$12,850
|
|
7-night Classic California Coast Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Royal Princess
|
Departs
10/25/25
|
From
$1,198
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/25/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/25/25
|
Call For Pricing
|
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/25/25
|
From
$3,339
|
|
7-night Wonders of Colombia with 3 Nights in Panama City Post-Cruise Cruise/Land Package
Cartagena to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/25/25
|
Call For Pricing
|
|
7-night Baja Peninsula Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/25/25
|
From
$1,254
|
|
14-night Baja Peninsula And Classic California Coast Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/25/25
|
From
$2,229
|
|
7-night Southern Caribbean Cruise
Roundtrip Colon (Panama) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
10/25/25
|
From
$1,648
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian New Build
|
Departs
10/26/25
|
From
$1,133
|
|
10-night From the Inca Empire to the Peruvian Amazon Cruise
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/26/25
|
From
$6,377
|
|
7-night St. Thomas, St. Kitts & Puerto Plata Cruise
Roundtrip Miami |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Beyond
|
Departs
10/26/25
|
From
$874
|
|
7-night Mexican Riviera Cruise: Cabo & Puerto Vallarta
Roundtrip Los Angeles |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Bliss
|
Departs
10/26/25
|
From
$1,005
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/26/25
|
From
$6,762
|
|
10-night Antarctica Cruise
Roundtrip Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Wind
|
Departs
10/26/25
|
Call For Pricing
|