Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
14-night Discover the Galápagos and Peru Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/19/25
|
From
$10,193
|
|
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/20/25
|
From
$5,664
|
|
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise and 3 Nights in Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/20/25
|
Call For Pricing
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/20/25
|
From
$409
|
|
9-night Heart Of The Amazon Cruise
Roundtrip Manaus (Amazon River) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Venture
|
Departs
10/21/25
|
From
$8,499
|
|
21-night The Complete Amazon Experience & Coast Of Brazil Cruise
Manaus (Amazon River) to Rio de Janeiro |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Venture
|
Departs
10/21/25
|
From
$16,199
|
|
23-night Panama Canal & Pacific Coast Cruise
Vancouver to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Coral Princess
|
Departs
10/21/25
|
From
$3,468
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/21/25
|
Call For Pricing
|
|
5-night Mexican Riviera Cruise: Cabo & Ensenada
Roundtrip Los Angeles |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Bliss
|
Departs
10/21/25
|
From
$653
|
|
4-night California Retreat Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Koningsdam
|
Departs
10/21/25
|
From
$539
|
|
18-night Panama Canal Cruise: Mexico & Colombia
San Francisco to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Encore
|
Departs
10/21/25
|
From
$2,042
|
|
16-night Panama Canal - Ocean To Ocean Cruise
Los Angeles to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Island Princess
|
Departs
10/22/25
|
From
$1,838
|
|
7-night Ecuador and Its Galápagos Islands Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/22/25
|
From
$6,709
|
|
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/22/25
|
From
$9,126
|
|
6-night Cabo Overnight and Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/22/25
|
From
$519
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/23/25
|
From
$6,523
|
|
10-night Classic Panama Canal Passage Cruise
Ft. Lauderdale to Panama Cty |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mars
|
Departs
10/23/25
|
From
$4,299
|
|
12-night Chilean Fjords & Scenic Shores Cruise
Santiago (Valparaiso) to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
10/23/25
|
From
$7,995
|
|
7-night Wonders of Colombia with 2 Nights Cartagena Pre-Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/23/25
|
From
$4,239
|
|
16-night Panama Canal Cruise: Mexico & Colombia
Los Angeles to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Encore
|
Departs
10/23/25
|
From
$1,960
|
|
10-night Quito and Galápagos Inner Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/24/25
|
Call For Pricing
|
|
7-night West Galapagos Expedition Cruise
Puerto Ayora to Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/24/25
|
Call For Pricing
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/24/25
|
From
$13,990
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/24/25
|
From
$13,196
|