Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
11-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/17/25
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Tampa |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Grandeur of the Seas
|
Departs
10/18/25
|
From
$619
|
|
8-night Southern Caribbean & Perfect Day Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Oasis of the Seas
|
Departs
10/18/25
|
From
$1,187
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/18/25
|
From
$8,154
|
|
15-night Hidden Galápagos and Peru Cruise/Land Package
Lima to Guayaquil |
Cruise Line
Tauck Cruises
|
Cruise Ship
Silver Origin for Tauck
|
Departs
10/18/25
|
From
$16,990
|
|
14-night Galapagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
10/18/25
|
Call For Pricing
|
|
7-night Galapagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
10/18/25
|
From
$12,850
|
|
7-night Mexican Riviera Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Royal Princess
|
Departs
10/18/25
|
From
$1,218
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/18/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/18/25
|
Call For Pricing
|
|
7-night Mexican Riviera Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/18/25
|
From
$891
|
|
14-night Mexican Riviera & Baja Peninsula Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/18/25
|
From
$2,294
|
|
10-night Magic of Colombia with 3 nights Medellin Soulful Experience Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/18/25
|
Call For Pricing
|
|
7-night Southern Caribbean Cruise
Roundtrip Colon (Panama) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
10/18/25
|
From
$1,769
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/18/25
|
Call For Pricing
|
|
21-night Antarctica, South Georgia, And The Falklands Southbound Cruise/Land Package
Roundtrip Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
10/18/25
|
From
$20,379
|
|
8-night Mexican Riviera Cruise: Cabo San Lucas & Puerto Vallarta
Roundtrip San Diego |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Jade
|
Departs
10/18/25
|
From
$797
|
|
7-night Galapagos Outer Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/19/25
|
From
$11,782
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian New Build
|
Departs
10/19/25
|
From
$1,183
|
|
14-night Discover the Galápagos and Peru Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/19/25
|
From
$10,193
|
|
19-night Discover the Galápagos and Peru with the Amazon Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/19/25
|
From
$12,770
|
|
7-night Southern Caribbean Cruise
Roundtrip Cartagena (Colombia) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
10/19/25
|
From
$2,127
|
|
20-night Panama Canal Cruise: Mexico & Colombia
Seattle to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Encore
|
Departs
10/19/25
|
From
$2,258
|
|
7-night Panama And Colombia Eastbound Cruise: Exploring The Caribbean Coast
Panama City to Cartagena |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Quest
|
Departs
10/19/25
|
From
$5,448
|