Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
17-night Panama & Scenic South America Cruise
Ft. Lauderdale to Santiago (Valparaiso) |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
10/13/25
|
From
$8,995
|
|
17-night Transpacific Cruise
Honolulu to Sydney |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Anthem of the Seas
|
Departs
10/13/25
|
From
$4,548
|
|
6-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/14/25
|
From
$6,864
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/14/25
|
Call For Pricing
|
|
18-night Song of Polynesia Voyage
Papeete to Los Angeles |
Cruise Line
Oceania Cruises
|
Cruise Ship
Regatta
|
Departs
10/15/25
|
From
$3,485
|
|
32-night South Pacific Islands & Hawaii Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Sapphire Princess
|
Departs
10/15/25
|
From
$4,268
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/15/25
|
From
$3,339
|
|
7-night Magic of Colombia with 3 Nights Panama City Post-Cruise Cruise/Land Package
Barranquilla to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/15/25
|
Call For Pricing
|
|
12-night Panama Canal With Costa Rica & Caribbean Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Caribbean Princess
|
Departs
10/16/25
|
From
$2,018
|
|
21-night Caribbean Cruise
Roundtrip Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
10/16/25
|
From
$2,320
|
|
6-night Cabo Overnight and Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/16/25
|
From
$523
|
|
10-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/17/25
|
Call For Pricing
|
|
11-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/17/25
|
Call For Pricing
|
|
7-night East Galapagos Expedition Cruise
Baltra Island to Puerto Ayora |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/17/25
|
Call For Pricing
|
|
14-night East & West Galapagos Expedition Cruise
Roundtrip Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/17/25
|
Call For Pricing
|
|
3-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/17/25
|
From
$353
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
10/17/25
|
From
$12,643
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
10/17/25
|
From
$6,605
|
|
17-night Alaska & Japan Cruise: Skagway, Ketchikan & Hakodate
Vancouver to Yokohama (Tokyo) |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Sun
|
Departs
10/17/25
|
From
$1,415
|
|
19-night Ocean Voyage: Lisbon - Buenos Aires
Lisbon to Buenos Aires |
Cruise Line
Ponant Cruises
|
Cruise Ship
L'Austral
|
Departs
10/17/25
|
From
$6,260
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/17/25
|
From
$9,940
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/17/25
|
From
$15,978
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/17/25
|
From
$13,196
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/17/25
|
From
$7,158
|