Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Cabo, Vallarta & Mazatlan Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/10/25
|
From
$695
|
|
7-night Classic California Coast Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Royal Princess
|
Departs
10/11/25
|
From
$1,208
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/11/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/11/25
|
Call For Pricing
|
|
7-night Classic California Coast Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/11/25
|
From
$1,204
|
|
14-night Classic California Coast And Mexican Riviera Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/11/25
|
From
$1,934
|
|
7-night Southern Caribbean Cruise
Roundtrip Colon (Panama) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
10/11/25
|
From
$1,768
|
|
14-night Caribbean Cruise: Curacao & Aruba
New York City to New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
10/11/25
|
From
$1,302
|
|
7-night Wonders Of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/11/25
|
From
$3,339
|
|
7-night Galapagos Inner Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/12/25
|
From
$9,132
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian New Build
|
Departs
10/12/25
|
From
$1,353
|
|
9-night Heart Of The Amazon Cruise
Roundtrip Belem |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Venture
|
Departs
10/12/25
|
From
$8,999
|
|
10-night From the Inca Empire to the Peruvian Amazon Cruise
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/12/25
|
From
$6,377
|
|
11-night South America Cruise
Santiago (Valparaiso) to Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Endeavour
|
Departs
10/12/25
|
Call For Pricing
|
|
7-night Classic California Coast Cruise
Roundtrip San Francisco |
Cruise Line
Princess Cruises
|
Cruise Ship
Ruby Princess
|
Departs
10/12/25
|
From
$1,238
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/12/25
|
From
$4,764
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/12/25
|
From
$6,762
|
|
4-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/12/25
|
From
$337
|
|
27-night South Pacific Crossing Cruise
Seattle to Sydney |
Cruise Line
Holland America Line
|
Cruise Ship
Noordam
|
Departs
10/12/25
|
Call For Pricing
|
|
41-night South Pacific Crossing & New Zealand Collector Cruise
Seattle to Aukland |
Cruise Line
Holland America Line
|
Cruise Ship
Noordam
|
Departs
10/12/25
|
Call For Pricing
|
|
16-night Antarctica And Patagonia: Legendary Ice And Epic Fjords Cruise
Buenos Aires to Punta Arenas |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Resolution
|
Departs
10/12/25
|
From
$24,398
|
|
17-night From The Inca Empire To The Peruvian Amazon With Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/12/25
|
Call For Pricing
|
|
7-night Southern Caribbean Cruise
Roundtrip Cartagena (Colombia) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
10/12/25
|
From
$2,379
|
|
46-night The Americas, Chile & Antarctica Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
10/13/25
|
From
$37,485
|