Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
10-night Peruvian Rivers and Rainforest Discovery Cruise/Land Package
Roundtrip Lima |
Cruise Line
Uniworld River Cruises
|
Cruise Ship
Aria Amazon
|
Departs
10/8/25
|
From
$14,399
|
|
15-night Peruvian Amazon and Machu Picchu Exploration Cruise/Land Package
Roundtrip Lima |
Cruise Line
Uniworld River Cruises
|
Cruise Ship
Aria Amazon
|
Departs
10/8/25
|
From
$16,499
|
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/8/25
|
Call For Pricing
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/9/25
|
From
$8,154
|
|
17-night Panama Canal Cruise
San Diego to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/9/25
|
From
$3,054
|
|
9-night Southern Caribbean Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Reflection
|
Departs
10/9/25
|
From
$1,422
|
|
7-night Wonders Of Colombia With 2-nights In Cartagena Pre Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/9/25
|
From
$4,239
|
|
24-night Panama Canal & Eastern Caribbean Cruise
San Diego to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/9/25
|
From
$4,289
|
|
10-night Quito and Galápagos Inner Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/10/25
|
Call For Pricing
|
|
11-night Quito and Galápagos Inner Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/10/25
|
Call For Pricing
|
|
20-night Easter & Pitcairn Islands: Marooned, Moai & Mutineers Cruise
Papeete to Santiago (San Antonio) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
10/10/25
|
From
$20,029
|
|
38-night Easter Island, Chilean Fjords & Antarctic Cruise
Papeete to Buenos Aires |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
10/10/25
|
Call For Pricing
|
|
12-night From the Inca Empire to the Peruvian Amazon with the Nazca Lines Cruise/Land Package
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/10/25
|
From
$7,477
|
|
10-night Wild Galapagos & Peru Escape Cruise
Lima to Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/10/25
|
From
$9,459
|
|
14-night Peru and the Galápagos Islands Cruise/Land Package
Lima to Guayaquil |
Cruise Line
Tauck Cruises
|
Cruise Ship
Isabela II
|
Departs
10/10/25
|
From
$14,090
|
|
23-night South Pacific to South America Cruise
Papeete to Santiago (Valparaiso) |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Cloud Expedition
|
Departs
10/10/25
|
From
$17,050
|
|
7-night West Galapagos Expedition Cruise
Puerto Ayora to Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/10/25
|
Call For Pricing
|
|
14-night West & East Galapagos Expedition Cruise
Roundtrip Puerto Ayora |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
10/10/25
|
Call For Pricing
|
|
7-night Cabo, Vallarta & Mazatlan Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/10/25
|
From
$695
|
|
9-night Patagonia: Chilean Fjords And Argentina’S Staten Island Cruise
Santiago to Ushuaia |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
10/10/25
|
From
$13,588
|
|
19-night From The Inca Empire To The Peruvian Amazon With The Nazca Lines & Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
10/10/25
|
Call For Pricing
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
10/10/25
|
From
$7,952
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/10/25
|
From
$6,818
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
10/10/25
|
From
$5,284
|