Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/4/25
|
From
$8,154
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/4/25
|
Call For Pricing
|
|
21-night Circle Hawaii & California Retreat Cruise
Vancover to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Koningsdam
|
Departs
10/4/25
|
From
$3,344
|
|
22-night Panama Canal Cruise
Seattle to Vancover |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/4/25
|
From
$3,899
|
|
9-night Upper Amazon Aboard The Delfin II Cruise
Roundtrip Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
Delfin II
|
Departs
10/4/25
|
From
$9,627
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/4/25
|
From
$3,839
|
|
7-night Galapagos Outer Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/5/25
|
From
$8,388
|
|
14-night Discover the Galápagos and Peru Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/5/25
|
From
$10,193
|
|
19-night Discover the Galápagos and Peru with the Amazon Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/5/25
|
From
$12,770
|
|
21-night Panama Canal Cruise
Vancover to Ft. Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/5/25
|
From
$3,624
|
|
21-night South America Cruise
Buenos Aires to Port Williams |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Wind
|
Departs
10/5/25
|
Call For Pricing
|
|
15-night Panama Canal Cruise: Mexico, Costa Rica & Colombia
Los Angeles to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Joy
|
Departs
10/5/25
|
From
$1,672
|
|
28-night Panama Canal & Eastern Caribbean Cruise
Vancouver to Ft.Lauderdale |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/5/25
|
From
$4,864
|
|
16-night Hawaiian Islands Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Island Princess
|
Departs
10/6/25
|
From
$2,758
|
|
40-night The Americas & Antarctic Explorer Cruise
Ft. Lauderdale to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
10/6/25
|
Call For Pricing
|
|
17-night Panama & Scenic South America Cruise
Ft. Lauderdale to Santiago (Valparaiso) |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
10/6/25
|
From
$7,995
|
|
7-night Wonders of Colombia with 2 Nights in Cartagena Pre-Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/6/25
|
Call For Pricing
|
|
6-night Cabo and Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/6/25
|
From
$595
|
|
7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/6/25
|
From
$5,664
|
|
13-night Best Of Chilean Patagonia: Fjords, Glaciers, And Torres Del Paine Southbound Cruise/Land Package
Santiago to Buenos Aires |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
10/6/25
|
From
$22,828
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/7/25
|
Call For Pricing
|
|
24-night Wild Coasts Of Argentina, South Georgia, And The Falklands Cruise
Buenos Aires to Ushuaia |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endurance
|
Departs
10/7/25
|
From
$25,058
|
|
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
10/8/25
|
From
$9,126
|
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/8/25
|
Call For Pricing
|