Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/1/25
|
From
$3,589
|
|
7-night Magic of Colombia with 3 Nights Panama City Post-Cruise Cruise/Land Package
Barranquilla to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/1/25
|
Call For Pricing
|
|
18-night Southern Caribbean Adventurer Cruise
Ft. Lauderdale to San Juan |
Cruise Line
Princess Cruises
|
Cruise Ship
Grand Princess
|
Departs
10/1/25
|
From
$2,834
|
|
11-night Southern Caribbean Islander Cruise
Ft. Lauderdale to San Juan |
Cruise Line
Princess Cruises
|
Cruise Ship
Grand Princess
|
Departs
10/1/25
|
From
$1,458
|
|
7-night Magic Of Colombia With 3-nights Medellín Pre Cruise Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/1/25
|
From
$5,264
|
|
4-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Quantum of the Seas
|
Departs
10/2/25
|
From
$399
|
|
18-night Panama Canal Cruise: Mexico, Costa Rica & Colombia
San Francisco to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Joy
|
Departs
10/2/25
|
From
$1,769
|
|
10-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/3/25
|
Call For Pricing
|
|
11-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/3/25
|
Call For Pricing
|
|
16-night Galápagos Outer Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
10/3/25
|
Call For Pricing
|
|
8-night Southern Caribbean & Perfect Day Cruise
Roundtrip Port Canaveral |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Adventure of the Seas
|
Departs
10/3/25
|
From
$1,237
|
|
7-night Wonders of Colombia with 3 Nights in Medellin and 2 Nights in Cartagena Pre-Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/3/25
|
Call For Pricing
|
|
7-night Cabo, Vallarta & Mazatlan Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
10/3/25
|
From
$643
|
|
14-night South Pacific Cruise From Honolulu Ending In Sydney
Honolulu to Sydney |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Wonder
|
Departs
10/3/25
|
From
$2,125
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
10/3/25
|
From
$6,818
|
|
7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise And 3-nights In Panama City Post Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
10/3/25
|
Call For Pricing
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
10/4/25
|
From
$8,154
|
|
7-night Mexican Riviera Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Royal Princess
|
Departs
10/4/25
|
From
$679
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/4/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
10/4/25
|
Call For Pricing
|
|
21-night Circle Hawaii & California Retreat Cruise
Vancover to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Koningsdam
|
Departs
10/4/25
|
From
$3,344
|
|
22-night Panama Canal Cruise
Seattle to Vancover |
Cruise Line
Holland America Line
|
Cruise Ship
Eurodam
|
Departs
10/4/25
|
From
$3,899
|
|
14-night Mexican Riviera And Classic California Coast Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
10/4/25
|
From
$2,309
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
10/4/25
|
From
$3,839
|