Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/27/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/27/25
|
Call For Pricing
|
|
52-night Fiji to the Chilean Coast & Antarctica Cruise
Lautoka to Buenos Aires |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Pursuit
|
Departs
9/27/25
|
Call For Pricing
|
|
9-night Upper Amazon Aboard The Delfin II Cruise
Roundtrip Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
Delfin II
|
Departs
9/27/25
|
From
$9,627
|
|
7-night Galapagos Inner Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/28/25
|
From
$8,218
|
|
10-night From the Inca Empire to the Peruvian Amazon Cruise
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
9/28/25
|
From
$6,377
|
|
15-night Alaska & North Pacific Crossing Cruise
Seattle to Yokohama (Tokyo) |
Cruise Line
Princess Cruises
|
Cruise Ship
Discovery Princess
|
Departs
9/28/25
|
From
$1,748
|
|
29-night Southeast Asia, Japan & Alaska Grand Adventure Cruise
Seattle to Singapore |
Cruise Line
Princess Cruises
|
Cruise Ship
Discovery Princess
|
Departs
9/28/25
|
From
$7,558
|
|
18-night San Francisco to Miami Cruise
San Francisco to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/28/25
|
Call For Pricing
|
|
30-night San Francisco to Miami Cruise
San Francisco to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/28/25
|
Call For Pricing
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/28/25
|
From
$5,014
|
|
7-night Magic of Colombia with 3 Nights Medellin Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/28/25
|
From
$7,012
|
|
13-night North Pacific Crossing Cruise
Seattle to Yokohama (Tokyo) |
Cruise Line
Holland America Line
|
Cruise Ship
Westerdam
|
Departs
9/28/25
|
From
$1,994
|
|
28-night North Pacific Crossing & Circle Japan Collector Cruise
Seattle to Tokyo |
Cruise Line
Holland America Line
|
Cruise Ship
Westerdam
|
Departs
9/28/25
|
Call For Pricing
|
|
13-night Mexican Riviera & Pacific Coast Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
9/28/25
|
From
$1,559
|
|
20-night Mexican Riviera, California And Pacific Coast Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Nieuw Amsterdam
|
Departs
9/28/25
|
From
$2,999
|
|
17-night From The Inca Empire To The Peruvian Amazon With Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
9/28/25
|
Call For Pricing
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
9/29/25
|
From
$350
|
|
51-night Tales Of The South Pacific Cruise
Roundtrip San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Zaandam
|
Departs
9/29/25
|
Call For Pricing
|
|
21-night Panama Canal Cruise: Mexico, Costa Rica & Colombia
Seattle to Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Joy
|
Departs
9/29/25
|
From
$1,874
|
|
12-night Caribbean Cruise: Dominican Republic & St. Lucia
Roundtrip New York City |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
9/29/25
|
From
$1,121
|
|
6-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
9/30/25
|
From
$6,934
|
|
16-night Panama Canal - Ocean To Ocean Cruise
Los Angeles to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Caribbean Princess
|
Departs
9/30/25
|
From
$1,908
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/30/25
|
Call For Pricing
|