Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,917 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Wonders of Colombia Cruise
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/24/25
|
Call For Pricing
|
|
10-night Wonders of Colombia with 3 nights in Panama City Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/24/25
|
Call For Pricing
|
|
11-night Mexican Riviera Cruise
Roundtrip San Francisco |
Cruise Line
Princess Cruises
|
Cruise Ship
Ruby Princess
|
Departs
9/24/25
|
From
$1,558
|
|
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
9/24/25
|
From
$9,126
|
|
56-night Tales Of The South Pacific Cruise
Vancouver to San Diego |
Cruise Line
Holland America Line
|
Cruise Ship
Zaandam
|
Departs
9/24/25
|
Call For Pricing
|
|
21-night Seattle to Miami Cruise
Seattle to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/25/25
|
From
$1,981
|
|
33-night Seattle to Miami Cruise
Seattle to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/25/25
|
From
$2,925
|
|
7-night Wonders Of Colombia With 2-nights In Cartagena Pre Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
9/25/25
|
From
$4,239
|
|
10-night Quito and Galápagos Inner Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/26/25
|
Call For Pricing
|
|
11-night Quito and Galápagos Inner Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/26/25
|
Call For Pricing
|
|
16-night Galápagos Inner Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/26/25
|
Call For Pricing
|
|
12-night From the Inca Empire to the Peruvian Amazon with the Nazca Lines Cruise/Land Package
Roundtrip Lima |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
9/26/25
|
From
$7,477
|
|
10-night Wild Galapagos & Peru Escape Cruise
Lima to Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
9/26/25
|
From
$9,755
|
|
14-night Peru and the Galápagos Islands Cruise/Land Package
Lima to Guayaquil |
Cruise Line
Tauck Cruises
|
Cruise Ship
Isabela II
|
Departs
9/26/25
|
From
$14,090
|
|
3-night Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
9/26/25
|
From
$342
|
|
19-night From The Inca Empire To The Peruvian Amazon With The Nazca Lines & Galápagos Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Delfin III
|
Departs
9/26/25
|
Call For Pricing
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
9/26/25
|
From
$11,715
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
9/26/25
|
From
$5,677
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/26/25
|
From
$7,952
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/26/25
|
From
$13,990
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/26/25
|
From
$12,856
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/26/25
|
From
$6,818
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/27/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/27/25
|
Call For Pricing
|