Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,919 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
16-night Galápagos Outer Loop and Machu Picchu Cruise/Land Package
Quito to Lima |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/19/25
|
Call For Pricing
|
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/19/25
|
Call For Pricing
|
|
7-night Wonders of Colombia with 3 nights in Medellin, 2 nights in Cartagena Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/19/25
|
Call For Pricing
|
|
16-night Panama Canal Eastbound Cruise
Los Angeles to Ft.Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Summit
|
Departs
9/19/25
|
From
$1,377
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/19/25
|
From
$7,952
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/19/25
|
From
$13,990
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/19/25
|
From
$12,856
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/19/25
|
From
$6,818
|
|
7-night Galápagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
9/20/25
|
From
$12,950
|
|
8-night Southern Caribbean & Perfect Day Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Oasis of the Seas
|
Departs
9/20/25
|
From
$1,285
|
|
3-night Amazon Discovery Cruise
Iquitos to Nauta |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/20/25
|
Call For Pricing
|
|
7-night Amazon Expeditions Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/20/25
|
Call For Pricing
|
|
9-night Southern Caribbean Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Reflection
|
Departs
9/20/25
|
From
$1,423
|
|
9-night Upper Amazon Aboard The Delfin II Cruise
Roundtrip Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
Delfin II
|
Departs
9/20/25
|
From
$9,145
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
9/20/25
|
From
$3,839
|
|
7-night Galapagos Outer Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/21/25
|
From
$7,713
|
|
11-night Hawaii Cruise
Vancouver to Honolulu |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Solstice
|
Departs
9/21/25
|
From
$1,355
|
|
14-night Discover the Galápagos and Peru Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
9/21/25
|
From
$10,193
|
|
19-night Discover the Galápagos and Peru with the Amazon Cruise/Land Package
Lima to Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
9/21/25
|
From
$12,770
|
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/22/25
|
Call For Pricing
|
|
7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise Cruise/Land Package
Medellin to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
9/22/25
|
From
$5,664
|
|
23-night Panama Canal & Pacific Coast Cruise
Vancouver to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Caribbean Princess
|
Departs
9/23/25
|
From
$3,418
|
|
10-night Hawaiian Cruise From Vancouver Ending In Honolulu
Vancouver to Honolulu |
Cruise Line
Disney Cruise Line
|
Cruise Ship
Disney Wonder
|
Departs
9/23/25
|
From
$2,300
|
|
15-night Los Angeles To Tokyo Cruise
Los Angeles to Yokohama (Tokyo) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Ovation of the Seas
|
Departs
9/23/25
|
From
$1,474
|