Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,893 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
61-night Longitudinal World Cruise Iv
Milwaukee to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Polaris
|
Departs
9/15/25
|
Call For Pricing
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
9/15/25
|
From
$343
|
|
16-night Panama Canal - Ocean To Ocean Cruise
Los Angeles to Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Grand Princess
|
Departs
9/15/25
|
From
$2,142
|
|
27-night Panama Canal and Caribbean Adventurer Cruise
Los Angeles to San Juan |
Cruise Line
Princess Cruises
|
Cruise Ship
Grand Princess
|
Departs
9/15/25
|
From
$3,828
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
9/16/25
|
Call For Pricing
|
|
19-night North Pacific Crossing Cruise
Vancouver to Yokohama (Tokyo) |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Explorer
|
Departs
9/17/25
|
From
$7,150
|
|
30-night Transpacific Quest Cruise
Vancouver to Tokyo |
Cruise Line
Regent Seven Seas Cruises
|
Cruise Ship
Seven Seas Explorer
|
Departs
9/17/25
|
From
$20,999
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/17/25
|
From
$3,339
|
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/17/25
|
Call For Pricing
|
|
6-night Cabo Overnight And Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Ovation of the Seas
|
Departs
9/17/25
|
From
$519
|
|
7-night Magic Of Colombia With 3-nights Medellín Pre Cruise Cruise/Land Package
Medellin to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
9/17/25
|
From
$5,264
|
|
19-night Glaciers To Timeless Japan Voyage
Seattle to Yokohama (Tokyo) |
Cruise Line
Oceania Cruises
|
Cruise Ship
Riviera
|
Departs
9/18/25
|
From
$5,199
|
|
18-night Panama Canal - Ocean To Ocean Cruise
New York City to Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Island Princess
|
Departs
9/18/25
|
From
$2,708
|
|
28-night Seattle to Miami Cruise
Seattle to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/18/25
|
From
$2,808
|
|
40-night Seattle to Miami Cruise
Seattle to Miami |
Cruise Line
Cunard Line
|
Cruise Ship
Queen Elizabeth
|
Departs
9/18/25
|
From
$3,929
|
|
11-night Quito and Galápagos Outer Loop Cruise/Land Package
Roundtrip Quito |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
9/19/25
|
Call For Pricing
|
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/19/25
|
Call For Pricing
|
|
12-night Hawaii Cruise
Vancouver to Honolulu |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Edge
|
Departs
9/19/25
|
From
$1,580
|
|
7-night Wonders of Colombia with 3 nights in Medellin, 2 nights in Cartagena Pre-Cruise and 3 Nights Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
9/19/25
|
Call For Pricing
|
|
22-night Pacific Passage & Jewels Of Japan Cruise
Vancouver to Yokohama (Tokyo) |
Cruise Line
Seabourn
|
Cruise Ship
Seabourn Quest
|
Departs
9/19/25
|
From
$9,174
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/19/25
|
From
$7,952
|
|
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
9/19/25
|
From
$13,990
|
|
15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package
Quito or Guayaquil to Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/19/25
|
From
$12,856
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Gemini
|
Departs
9/19/25
|
From
$6,818
|