Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
5,893 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
5/16/25
|
From
$11,351
|
|
7-night Magic of Colombia Cruise
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/17/25
|
From
$3,839
|
|
7-night Eastern Caribbean With Puerto Rico Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Enchanted Princess
|
Departs
5/17/25
|
Call For Pricing
|
|
14-night Caribbean East/West Adventurer Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Enchanted Princess
|
Departs
5/17/25
|
Call For Pricing
|
|
18-night Panama Canal - Ocean To Ocean Cruise
Los Angeles to New York City |
Cruise Line
Princess Cruises
|
Cruise Ship
Island Princess
|
Departs
5/17/25
|
Call For Pricing
|
|
10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package
Barranquilla to Cartagena |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/17/25
|
Call For Pricing
|
|
7-night Galápagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
5/17/25
|
Call For Pricing
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Port Canaveral |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian New Build
|
Departs
5/17/25
|
From
$1,779
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
5/17/25
|
From
$10,908
|
|
9-night Upper Amazon Aboard The Delfin II Cruise
Roundtrip Lima |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
Delfin II
|
Departs
5/17/25
|
From
$9,145
|
|
7-night Galapagos Outer Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
5/18/25
|
From
$10,588
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Escape
|
Departs
5/18/25
|
From
$1,451
|
|
12-night Wonders of Colombia with 3 nights in Medellin and 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/19/25
|
From
$6,164
|
|
7-night Wonders of Colombia with 3 Nights in Medellin, 2 Nights in Cartagena Pre-Cruise and 3 Nights in Panama City Post-Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/19/25
|
From
$8,162
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
5/19/25
|
From
$715
|
|
7-night Panama Canal Cruise
Fuerte Amador (Panama City) to Ft. Lauderdale |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Shadow
|
Departs
5/20/25
|
From
$12,200
|
|
7-night Ecuador and Its Galápagos Islands Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
5/21/25
|
From
$6,599
|
|
11-night Ecuador and Its Galápagos Islands with the Amazon Cruise/Land Package
Roundtrip Quito |
Cruise Line
Avalon Waterways
|
Cruise Ship
Treasure of Galápagos
|
Departs
5/21/25
|
From
$9,016
|
|
9-night Wonders of Colombia with 2 nights in Cartagena Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
5/22/25
|
From
$4,739
|
|
7-night Wild Galapagos Escape Cruise
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Islander II
|
Departs
5/22/25
|
From
$10,719
|
|
7-night West Galapagos Expedition Cruise
Puerto Ayora to Baltra Island |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Mare
|
Departs
5/23/25
|
Call For Pricing
|
|
7-night Cabo, Vallarta & Mazatlan Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Navigator of the Seas
|
Departs
5/23/25
|
Call For Pricing
|
|
9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package
Roundtrip Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Endeavour II
|
Departs
5/23/25
|
From
$8,775
|
|
9-night Galápagos By Catamaran: An Intimate Voyage Cruise/Land Package
Roundtrip Quito or Guayaquil |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Delfina
|
Departs
5/23/25
|
From
$11,116
|