Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

6,368 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

43-night Australia, New Zealand & South Pacific Crossing Cruise

Auckland to Seattle

Cruise Line
Holland America Line
Cruise Ship
Noordam
Departs
3/14/27
From
$8,854
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan

Roundtrip New Orleans

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Prima
Departs
3/14/27
 
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6-night Western Caribbean Cruise

Roundtrip Tampa

Cruise Line
Royal Caribbean International
Cruise Ship
Rhapsody of the Seas
Departs
3/14/27
14-night Western & Eastern Caribbean Cruise: Mexico & Bahamas

Roundtrip Ft. Lauderdale

Cruise Line
Holland America Line
Cruise Ship
Nieuw Statendam
Departs
3/14/27
From
$3,164
5-night Western Caribbean Cruise

Roundtrip Miami

Cruise Line
Royal Caribbean International
Cruise Ship
Freedom of the Seas
Departs
3/15/27
5-night Western Caribbean Cruise

Roundtrip Galveston

Cruise Line
Royal Caribbean International
Cruise Ship
Liberty of the Seas
Departs
3/15/27
10-night Panama & Pristine Isles Voyage

Panama City to Miami

Cruise Line
Oceania Cruises
Cruise Ship
Marina
Departs
3/15/27
From
$3,199
6-night Wild Galapagos Escape Cruise

Roundtrip Quito or Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
3/16/27
 
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16-night Hawaiian Islands Cruise

Roundtrip San Francisco

Cruise Line
Princess Cruises
Cruise Ship
Ruby Princess
Departs
3/16/27
From
$2,509
10-night Emblematic South American Shores and Cities

Buenos Aires to Rio De Janeiro

Cruise Line
Ponant Cruises
Cruise Ship
L'Austral
Departs
3/16/27
From
$7,020
4-night Amazon Explorer Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
3/16/27
 
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10-night Eastern Caribbean With St. Kitts Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
3/17/27
From
$1,569
7-night Magic Of Colombia Cruise

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMelodia
Departs
3/17/27
From
$3,749
5-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic

Roundtrip Port Canaveral

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Getaway
Departs
3/17/27
 
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7-night Magic Of Colombia With 3-nights Medellín Pre Cruise Cruise/Land Package

Medellin to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
3/17/27
From
$5,309
16-night Panama Canal Cruise - Ocean To Ocean

Ft. Lauderdale to Los Angeles

Cruise Line
Princess Cruises
Cruise Ship
Island Princess
Departs
3/18/27
From
$2,359
3-night Ensenada Cruise

Roundtrip San Diego

Cruise Line
Royal Caribbean International
Cruise Ship
Serenade of the Seas
Departs
3/18/27
15-night Galápagos By Catamaran + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package

Quito or Guayaquil to Lima

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Delfina
Departs
3/19/27
 
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15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package

Quito or Guayaquil to Lima

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Gemini
Departs
3/19/27
 
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9-night Exploring Galápagos: One Week Sailing The Islands Cruise/Land Package

Roundtrip Quito or Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Gemini
Departs
3/19/27
 
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15-night Exploring Galápagos + Machu Picchu And Peru's Land Of The Inca Cruise/Land Package

Quito or Guayaquil to Lima

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Endeavour II
Departs
3/19/27
 
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7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic

Roundtrip Port Canaveral

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Escape
Departs
3/19/27
 
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11-night Quito & Galapagos Outer Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
3/19/27
 
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21-night Amazonian Spirit Voyage

Rio de Janeiro to Miami

Cruise Line
Oceania Cruises
Cruise Ship
Insignia
Departs
3/19/27
From
$6,299