Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.
Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.
There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.
6,368 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
| Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
|---|---|---|---|---|
|
7-night Galapagos Islands Cruise
Roundtrip Isla San Cristobal |
Cruise Line
Silversea Cruises
|
Cruise Ship
Silver Origin
|
Departs
12/12/26
|
From
$12,750
|
|
7-night Galapagos Outer Loop Cruise
Roundtrip Isla Baltra |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Flora
|
Departs
12/13/26
|
From
$11,844
|
|
7-night The Panama Canal, Pearl Islands, And Darién Jungle Northbound Cruise: Tropical Wonders And Vibrant Cultures
Roundtrip Panama City |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Quest
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night St. Thomas, San Juan & Bahamas Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Celebrity Cruises
|
Cruise Ship
Celebrity Beyond
|
Departs
12/13/26
|
From
$1,053
|
|
14-night Eastern/Western Caribbean Adventurer Cruise
Roundtrip Ft. Lauderdale |
Cruise Line
Princess Cruises
|
Cruise Ship
Sun Princess
|
Departs
12/13/26
|
From
$2,699
|
|
8-night Eastern Caribbean Cruise With Puerto Rico
Roundtrip Port Canaveral |
Cruise Line
Princess Cruises
|
Cruise Ship
Sky Princess
|
Departs
12/13/26
|
From
$1,174
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Dominican Republic
Roundtrip Miami |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian New Build
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Mexican Riviera Cruise: Cabo San Lucas & Puerto Vallarta
Roundtrip Los Angeles |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Encore
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Caribbean Cruise: Great Stirrup Cay & Cozumel
Roundtrip Port Canaveral |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Epic
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Caribbean Cruise: Dominican Republic & Bahamas
Roundtrip Jacksonville |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Caribbean Cruise: Harvest Caye, Cozumel & Roatan
Roundtrip New Orleans |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Prima
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Western Caribbean Cruise
Roundtrip Tampa |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Enchantment of the Seas
|
Departs
12/13/26
|
Call For Pricing
|
|
7-night Cabo Overnight, Catalina & Ensenada Cruise
Roundtrip San Diego |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Serenade of the Seas
|
Departs
12/13/26
|
From
$728
|
|
7-night Southern Caribbean Cruise
Roundtrip Cartagena (Columbia) |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Jewel of the Seas
|
Departs
12/13/26
|
From
$1,287
|
|
7-night Antarctica Direct: Fly The Drake Passage Cruise
Roundtrip Puerto Natales |
Cruise Line
Lindblad Expeditions
|
Cruise Ship
National Geographic Explorer
|
Departs
12/14/26
|
Call For Pricing
|
|
7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise Cruise/Land Package
Medellin to Baranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
12/14/26
|
From
$6,299
|
|
7-night Wonders Of Colombia With 3-nights In Medellín, 2-nights In Cartagena Pre Cruise And 3-nights In Panama City Post Cruise Cruise/Land Package
Medellin to Panama City |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMagdalena
|
Departs
12/14/26
|
From
$8,474
|
|
16-night Hawaiian Islands Holiday Cruise
Roundtrip Los Angeles |
Cruise Line
Princess Cruises
|
Cruise Ship
Emerald Princess
|
Departs
12/14/26
|
From
$2,829
|
|
4-night Catalina & Ensenada Cruise
Roundtrip Los Angeles |
Cruise Line
Royal Caribbean International
|
Cruise Ship
Ovation of the Seas
|
Departs
12/14/26
|
From
$461
|
|
7-night Wonders Of Colombia With 2-nights In Cartagena Pre Cruise Cruise/Land Package
Cartagena to Barranquilla |
Cruise Line
AmaWaterways
|
Cruise Ship
AmaMelodia
|
Departs
12/14/26
|
From
$4,739
|
|
7-night Tropical Retreats Voyage
Roundtrip Miami |
Cruise Line
Oceania Cruises
|
Cruise Ship
Vista
|
Departs
12/14/26
|
From
$2,899
|
|
11-night Mexican Riviera Holiday Cruise
Roundtrip San Francisco |
Cruise Line
Princess Cruises
|
Cruise Ship
Ruby Princess
|
Departs
12/15/26
|
From
$1,659
|
|
12-night Antarctic Explorer Cruise
Buenos Aires to Ushuaia |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Octantis
|
Departs
12/15/26
|
From
$13,195
|
|
4-night Amazon Explorer Cruise
Roundtrip Iquitos |
Cruise Line
Aqua Expeditions
|
Cruise Ship
Aqua Nera
|
Departs
12/15/26
|
Call For Pricing
|