2021 US River Cruises With American Cruise Lines

Specials / 2021 US River Cruises With American Cruise Lines
Cruise Line American Cruise Lines
Prices From $2,290
Expires 11/30/21

Start cruising now and stay close to home on the beautiful rivers of the United States with American Cruise Lines.

With American Cruise Lines, you can explore so much beauty right here at home. Choose from a variety of itineraries traveling to the most amazing destinations of the United States like Alaska, Mississippi River, New England and so much more. Get back to traveling this year and enjoy included amenities, personalized service and an all-American experience on a United States river cruise with American Cruise Lines. Reserve your cruise with us and get a complimentary bottle of wine on any sailing!

Search the sailings below or call us at 1 (877) 734-6858 to start planning your river cruise for this year!

Connect With A CruiseInsider Expert About This Special Offer!

Submit the form below or call us at 1 (877) 734-6858

Includes free extras and bonus savings available only from CruiseInsider.

7-night Columbia and Snake Rivers Cruise

Clarkston to Portland

Cruise Line
American Cruise Lines
Cruise Ship
American Song
Departs
11/7/21
 
Call For Pricing
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
11/7/21
From
$5,115
7-night Columbia and Snake Rivers Cruise

Clarkston to Portland

Cruise Line
American Cruise Lines
Cruise Ship
American Harmony
Departs
11/10/21
 
Call For Pricing
7-night Columbia and Snake Rivers Cruise

Clarkston to Portland

Cruise Line
American Cruise Lines
Cruise Ship
American Pride
Departs
11/12/21
 
Call For Pricing
7-night Puget Sound and San Juan Islands Cruise

Roundtrip Seattle

Cruise Line
American Cruise Lines
Cruise Ship
American Constellation
Departs
11/12/21
 
Call For Pricing
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
11/13/21
From
$4,785
7-night Historic South and Golden Isles Cruise

Charleston, SC to Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
11/13/21
From
$4,215
4-night Highlights of the Mississippi River Cruise

Roundtrip New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
America
Departs
11/13/21
From
$2,830
7-night Chesapeake Bay Cruise

Roundtrip Baltimore

Cruise Line
American Cruise Lines
Cruise Ship
American Constitution
Departs
11/14/21
From
$4,065
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
11/14/21
From
$5,115
7-night Columbia and Snake Rivers Cruise

Portland to Clarkston

Cruise Line
American Cruise Lines
Cruise Ship
American Song
Departs
11/14/21
 
Call For Pricing
7-night Columbia and Snake Rivers Cruise

Portland to Clarkston

Cruise Line
American Cruise Lines
Cruise Ship
American Harmony
Departs
11/17/21
 
Call For Pricing
4-night Highlights of the Mississippi River Cruise

Roundtrip New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
America
Departs
11/17/21
From
$2,290
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Melody
Departs
11/19/21
From
$5,115
7-night Columbia and Snake Rivers Cruise

Portland to Clarkston

Cruise Line
American Cruise Lines
Cruise Ship
American Pride
Departs
11/19/21
 
Call For Pricing
7-night Historic South and Golden Isles Cruise

Jacksonville to Fort Sumter, SC

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
11/20/21
From
$5,210
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
11/20/21
 
Call For Pricing
7-night Great Rivers of Florida Cruise

Roundtrip Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
American Star
Departs
11/21/21
From
$4,215
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
11/21/21
From
$4,615
7-night New Orleans to New Orleans Cruise

Roundtrip New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
America
Departs
11/21/21
From
$4,460
10-night American Revolution Cruise

Roundtrip Baltimore

Cruise Line
American Cruise Lines
Cruise Ship
American Constitution
Departs
11/21/21
From
$5,835
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Melody
Departs
11/26/21
 
Call For Pricing
7-night Columbia and Snake Rivers Cruise

Clarkston to Portland

Cruise Line
American Cruise Lines
Cruise Ship
American Pride
Departs
11/26/21
 
Call For Pricing
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
11/27/21
From
$4,785
7-night Historic South and Golden Isles Cruise

Charleston, SC to Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
11/27/21
From
$5,210
7-night Great Rivers of Florida Cruise

Roundtrip Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
American Star
Departs
11/28/21
From
$4,215
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
11/28/21
From
$5,115
7-night Columbia and Snake Rivers Cruise

Portland to Clarkston

Cruise Line
American Cruise Lines
Cruise Ship
American Song
Departs
11/28/21
 
Call For Pricing
10-night American Revolution Cruise

Roundtrip Baltimore

Cruise Line
American Cruise Lines
Cruise Ship
American Constitution
Departs
12/1/21
From
$4,610
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Melody
Departs
12/3/21
From
$5,330
7-night Historic South and Golden Isles Cruise

Jacksonville to Fort Sumter, SC

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
12/4/21
From
$5,455
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
12/4/21
From
$4,215
7-night Great Rivers of Florida Cruise

Roundtrip Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
American Star
Departs
12/5/21
From
$3,930
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
12/5/21
 
Call For Pricing
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Melody
Departs
12/10/21
From
$4,115
7-night Historic South and Golden Isles Cruise

Charleston, SC to Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
12/11/21
From
$7,455
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
12/12/21
 
Call For Pricing
10-night American Revolution Cruise

Roundtrip Baltimore

Cruise Line
American Cruise Lines
Cruise Ship
American Constitution
Departs
12/12/21
 
Call For Pricing
7-night Great Rivers of Florida Cruise

Roundtrip Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
American Star
Departs
12/12/21
From
$3,930
7-night Historic South and Golden Isles Cruise

Jacksonville to Charleston

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
12/20/21
From
$5,210
7-night Mississippi River Cruise

Roundtrip New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
12/20/21
From
$4,855
7-night Lower Mississippi River Cruise

New Orleans to Memphis

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
12/20/21
 
Call For Pricing
10-night American Revolution Cruise

Roundtrip Baltimore

Cruise Line
American Cruise Lines
Cruise Ship
American Constitution
Departs
12/23/21
From
$6,190
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Jazz
Departs
12/28/21
 
Call For Pricing
7-night Historic South and Golden Isles Cruise

Charleston to Jacksonville

Cruise Line
American Cruise Lines
Cruise Ship
Independence
Departs
12/28/21
 
Call For Pricing
7-night Mississippi River Cruise

Roundtrip New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
Queen of the Mississippi
Departs
12/28/21
From
$4,855
7-night Lower Mississippi River Cruise

Memphis to New Orleans

Cruise Line
American Cruise Lines
Cruise Ship
American Melody
Departs
12/28/21
From
$4,615

Terms and Conditions

Fares/rates are per person, based on double occupancy for select sail and travel dates; are capacity controlled and subject to availability at time booking and may be pulled without notice. We reserve the right to correct errors. Information and pricing is subject to change without notice. While we do our very best to ensure that information and pricing appearing in this website is complete and accurate, we cannot be responsible for incomplete and inaccurate representations, which may or may not be under our control. In the event of a pricing error, misrepresentation or omission, we reserve the right to adjust the pricing or make any other corrections.