Cruise lines sail to worldwide destinations from all over the United States, and whether you fly into a port city or drive there from nearby, each location offers its own charm, culture, climate and cuisine that will round out any cruise vacation. The heart of America beats through an eclectic collection of pulsating metropolises, iconic landscapes, interesting attractions, and off-the-beaten path oases. Whether you're relaxing on a Texas coastline, touring the historic cities of the Southeast, or enjoying the urban landscapes of the Northeast – no matter where your cruise departs from, America is certain to take your breath away.
836 cruises cruises
Includes free extras and bonus savings available only from CruiseInsider.
Itinerary | Cruise Line | Cruise Ship | Departing | From Price |
---|---|---|---|---|
7-night Bermuda & Maine Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
5/10/24
|
From
$299
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/11/24
|
Call For Pricing
|
7-night Historic South and Golden Isles Cruise
Charleston, SC to Jacksonville |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Eagle
|
Departs
5/13/24
|
Call For Pricing
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
5/13/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
5/14/24
|
Call For Pricing
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Star
|
Departs
5/16/24
|
Call For Pricing
|
7-night Bermuda & Maine Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
5/17/24
|
From
$499
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
5/17/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/17/24
|
Call For Pricing
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
5/20/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
5/21/24
|
Call For Pricing
|
11-night Heart of the Delta Cruise/Land Package
New Orleans to Memphis |
Cruise Line
Viking Cruises
|
Cruise Ship
Viking Mississippi
|
Departs
5/23/24
|
From
$6,999
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/23/24
|
Call For Pricing
|
7-night Chesapeake Bay Cruise
Roundtrip Baltimore |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Star
|
Departs
5/23/24
|
Call For Pricing
|
7-night Bermuda & Maine Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
5/24/24
|
From
$549
|
7-night Canada & New England Discovery Cruise
Boston to Montreal |
Cruise Line
Holland America Line
|
Cruise Ship
Volendam
|
Departs
5/25/24
|
From
$1,004
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
5/27/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Splendor
|
Departs
5/28/24
|
Call For Pricing
|
7-night Historic Mississippi River Cruise
Roundtrip New Orleans |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
5/29/24
|
Call For Pricing
|
7-night Bermuda & Maine Cruise
Roundtrip Boston |
Cruise Line
Norwegian Cruise Line
|
Cruise Ship
Norwegian Gem
|
Departs
5/31/24
|
From
$599
|
22-night Complete Mississippi River Cruise
New Orleans to St. Paul |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Melody
|
Departs
5/31/24
|
Call For Pricing
|
7-night Cape Codder Cruise
Roundtrip Boston |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Glory
|
Departs
6/3/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Heritage
|
Departs
6/4/24
|
Call For Pricing
|
8-night Lower Mississippi River Cruise
New Orleans to Memphis |
Cruise Line
American Cruise Lines
|
Cruise Ship
American Serenade
|
Departs
6/4/24
|
Call For Pricing
|