Central & South America

Destinations / Central & South America

Whether you’re an archaeology buff, outdoor adventurer or action-seeker, Central and South America won’t disappoint. With so many diverse travel options and unique destinations to see, an adventure to Central and South America means you’ll be surrounded by warm people, wondrous nature and wild adventure throughout your journey.

Visit the ancient Inca capital of Cuzco. Zipline through the jungles of Costa Rica. Explore the lost city of Machu Picchu. Relax on the warm beaches of Mexico. Immerse yourself in the rich culture of Brazil. Experience the biodiversity of the Amazon rainforest. There are miles of beautiful beaches, endless rivers, metropolitan cities, unexplored rainforest and countless mythical and memorable sites scattered throughout the continent. And you can see it all while being pampered every stop along the way on a luxury cruise.

There are dozens of cruise options to Central and South America, so speak to a CruiseInsider today at 1 (877) 734-6858 to start planning your own unique experience or choose from one of the many voyages offered below.

Central & South America Cruises

4,999 cruises cruises

Includes free extras and bonus savings available only from CruiseInsider.

11-night Quito and Galápagos Outer Loop Cruise/Land Package

Roundtrip Quito

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
4/18/25
From
$11,208
7-night East Galapagos Expedition Cruise

Baltra Island to Puerto Ayora

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
4/18/25
 
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14-night East & West Galapagos Expedition Cruise

Roundtrip Baltra Island

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Mare
Departs
4/18/25
 
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7-night Galapagos Southern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xpedition
Departs
4/19/25
From
$6,195
7-night Galapagos Northern Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Xploration
Departs
4/19/25
From
$6,307
7-night Magic of Colombia Cruise

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/19/25
From
$3,599
7-night Classic California Coast Cruise

Roundtrip San Diego

Cruise Line
Holland America Line
Cruise Ship
Zaandam
Departs
4/19/25
7-night Eastern Caribbean With Puerto Rico Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
4/19/25
14-night Caribbean East/West Adventurer Cruise

Roundtrip Ft. Lauderdale

Cruise Line
Princess Cruises
Cruise Ship
Enchanted Princess
Departs
4/19/25
 
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14-night Mexican Riviera & Classic California Coast Cruise

Roundtrip San Diego

Cruise Line
Holland America Line
Cruise Ship
Zaandam
Departs
4/19/25
From
$1,919
7-night Mexican Riviera Cruise

Roundtrip Los Angeles

Cruise Line
Princess Cruises
Cruise Ship
Discovery Princess
Departs
4/19/25
 
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10-night Magic of Colombia with 3 Nights Panama Cruise/Land Package

Barranquilla to Cartagena

Cruise Line
AmaWaterways
Cruise Ship
AmaMagdalena
Departs
4/19/25
 
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7-night Galápagos Islands Cruise

Roundtrip Isla San Cristobal (Puerto Baquerizo Moreno)

Cruise Line
Silversea Cruises
Cruise Ship
Silver Origin
Departs
4/19/25
From
$13,700
15-night Panama Canal Cruise

Tampa to Los Angeles

Cruise Line
Royal Caribbean International
Cruise Ship
Radiance of the Seas
Departs
4/19/25
From
$1,262
7-night Wild Galapagos Escape Cruise

Roundtrip Guayaquil

Cruise Line
Lindblad Expeditions
Cruise Ship
National Geographic Islander II
Departs
4/19/25
From
$11,478
15-night Hidden Galápagos and Peru Cruise/Land Package

Lima to Guayaquil

Cruise Line
Tauck Cruises
Cruise Ship
Silver Origin for Tauck
Departs
4/19/25
 
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3-night Amazon Discovery Cruise

Iquitos to Nauta

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
4/19/25
 
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7-night Amazon Expeditions Cruise

Roundtrip Iquitos

Cruise Line
Aqua Expeditions
Cruise Ship
Aqua Nera
Departs
4/19/25
 
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18-night Tahitian Treasures Cruise

Sydney to Oahu

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Edge
Departs
4/20/25
From
$3,564
7-night Galapagos Outer Loop Cruise

Roundtrip Isla Baltra

Cruise Line
Celebrity Cruises
Cruise Ship
Celebrity Flora
Departs
4/20/25
From
$9,088
7-night Classic California Coast Cruise

Roundtrip San Francisco

Cruise Line
Princess Cruises
Cruise Ship
Ruby Princess
Departs
4/20/25
 
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11-night Grand Caribbean Cruise

New Orleans to New York City

Cruise Line
Norwegian Cruise Line
Cruise Ship
Norwegian Getaway
Departs
4/20/25
From
$1,199
14-night Discover the Galápagos and Peru Cruise/Land Package

Lima to Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
4/20/25
From
$9,973
19-night Discover the Galápagos and Peru with the Amazon Cruise/Land Package

Lima to Quito

Cruise Line
Avalon Waterways
Cruise Ship
Treasure of Galápagos
Departs
4/20/25
From
$12,550